Gene: FGF19
Official Full Name: fibroblast growth factor 19provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10803 | FGF19 Knockout cell line (HCT 116) | Human | FGF19 | 1:2~1:4 | Negative | Online Inquiry |
FGF19 Gene Knockout Cell Lines represent a pivotal tool in modern biological research, specifically designed to study the functional roles of the fibroblast growth factor 19 (FGF19) gene. These genetically modified cell lines are developed through precise CRISPR/Cas9 genome-editing technology, which facilitates the targeted disruption of the FGF19 gene, enabling researchers to explore its associated biological pathways and molecular processes.
The key mechanism by which FGF19 functions is its role as a hormone in the regulation of bile acid synthesis and metabolism, impacting energy homeostasis and glucose metabolism. By knocking out the FGF19 gene in specific cell lines, researchers can elucidate the gene's involvement in metabolic disorders, liver functions, and its potential implications in diseases such as non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome. This model serves as an invaluable resource for studying the cellular responses to altered FGF19 signaling and understanding how this pathway can be targeted therapeutically.
The scientific importance of FGF19 Gene Knockout Cell Lines extends to both foundational research and applied biomedical studies. They offer advantages over traditional models, such as primary cells or animal studies, by providing a controlled environment that reduces variability and enhances reproducibility. Furthermore, these cell lines allow for high-throughput screening of therapeutic compounds and facilitate the rapid assessment of gene function in a cost-effective manner.
Researchers and clinicians will find exceptional value in utilizing FGF19 Gene Knockout Cell Lines due to their ability to streamline investigations into metabolic health, supporting the discovery of novel treatments and interventions. Moreover, the specificity of this product sets it apart from alternative models that may not offer the same precision or focus on the FGF19 pathway.
With expertise in developing cutting-edge biological tools, our company is dedicated to advancing research capabilities. We offer a comprehensive range of genetic models that empower scientists to drive discoveries, enhance reproducibility, and ultimately translate findings into meaningful clinical applications. By choosing FGF19 Gene Knockout Cell Lines, you invest in a foundational resource that will propel your research and clinical objectives forward.
Please note that all services are for research use only. Not intended for any clinical use.
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