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FGA Knockout Cell Lines

Gene: FGA

Official Full Name: fibrinogen alpha chainprovided by HGNC

Gene Summary: This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00217 FGA gRNA5-gRNA6 KO plasmid FGA $850
GP00224 FGA gRNA1-gRNA2 KO plasmid FGA $850
KO00635 FGA Knockout cell line(Hep G2) Human FGA 1:2~1:4 Negative Online Inquiry
KO06293 FGA Knockout cell line (A549) Human FGA 1:3~1:4 Negative Online Inquiry

Background

FGA Gene Knockout Cell Lines are specifically engineered cell lines in which the FGA gene, encoding fibrinogen alpha chain, has been disrupted via targeted genome editing methodologies, such as CRISPR/Cas9. This innovative approach facilitates the study of gene function through observation of phenotypic changes resulting from gene knockout, enabling researchers to unlock the biological significance of FGA in various physiological processes.

The functionality of FGA Gene Knockout Cell Lines lies in their ability to provide a controlled environment where specific genetic alterations can be observed in real-time. By removing the expression of the FGA gene, researchers can intricately analyze the effects on cellular behavior, signaling pathways, and protein interactions, particularly those related to coagulation, inflammation, and cellular adhesion. This precision opens pathways for further understanding of diseases such as thromboembolic disorders and other disorders linked to fibrinogen function.

The scientific importance of these knockout cell lines cannot be overstated, as they serve as vital tools in basic and applied research. In clinical settings, FGA Gene Knockout Cell Lines are invaluable for drug discovery, allowing for the testing of potential therapeutic compounds that target the pathways involving FGA, thus advancing therapeutic strategies.

What sets FGA Gene Knockout Cell Lines apart from alternative models is their unmatched specificity and reproducibility. These cell lines are derived from well-characterized backgrounds, ensuring reliability in research findings. Additionally, the ability to create and maintain knockout lines in a variety of host cell types broadens their applicability across multiple research disciplines.

For researchers, clinicians, and pharmaceutical companies, the FGA Gene Knockout Cell Lines provide a robust platform that fast-tracks discovery and innovation. This product not only enhances the understanding of fibrinogen biology but also strategically positions users at the forefront of therapeutic advancements.

Our company has a proven track record in generating high-quality biological research products, supported by a dedicated team of experts in gene editing and cellular biology. Our commitment to innovation ensures that we deliver cutting-edge solutions tailored to meet the specific needs of our clients in the research and clinical communities.

Please note that all services are for research use only. Not intended for any clinical use.

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