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FEZ1 Knockout Cell Lines

Gene: FEZ1

Official Full Name: fasciculation and elongation protein zeta 1provided by HGNC

Gene Summary: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33007 FEZ1 Knockout cell line (HCT 116) Human FEZ1 1:2~1:4 Negative Online Inquiry
KO33008 FEZ1 Knockout cell line (A549) Human FEZ1 1:3~1:4 Negative Online Inquiry

Background

FEZ1 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted gene disruption to create a deficiency in the FEZ1 gene. This product is integral for studies focusing on neural development, synaptic function, and various cellular signaling pathways, as FEZ1 is known to play a crucial role in neuronal differentiation and axonal growth. The knockout technology used in these cell lines allows for precise examination of the cellular effects attributable to the loss of FEZ1 function, thus facilitating investigations into its biological significance.

The primary mechanism of action for the FEZ1 Gene Knockout Cell Lines lies in the CRISPR/Cas9 or similar gene-editing systems employed to efficiently and accurately knock out the FEZ1 gene. This gene disruption alters the expression of downstream effectors involved in synaptic stability and neuron communication, thereby providing valuable insights into the phenotypes associated with FEZ1 deficiency, including changes in morphology and functionality of neural cells.

In research settings, these knockout cell lines are indispensable tools for investigating the pathophysiological mechanisms underlying neurodevelopmental disorders and neurodegenerative diseases, potentially revealing novel therapeutic targets. Clinically, understanding the role of the FEZ1 gene may help in elucidating its involvement in various malfunctions linked to neuronal health, thereby influencing treatment strategies in neurology.

Compared with conventional knockdown methods, which may lead to incomplete or transient disruptions, the FEZ1 Gene Knockout Cell Lines provide a stable and heritable model for long-term studies. This contributes to reproducibility and reliability in experimental results, essential qualities for impactful scientific research.

For researchers and clinicians seeking to delve deeper into the complexities of neuron biology, these cell lines represent a significant step forward. They enable a nuanced exploration of the FEZ1 gene's role in health and disease, contributing to the advancement of neurological science and therapeutic innovation.

Our company is committed to providing high-quality biological products and expertly engineered cell lines, ensuring that researchers have access to the most reliable tools needed to push the boundaries of scientific understanding.

Please note that all services are for research use only. Not intended for any clinical use.

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