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FCGR2C Knockout Cell Lines

Gene: FCGR2C

Official Full Name: Fc gamma receptor IIc (gene/pseudogene)provided by HGNC

Gene Summary: This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33586 FCGR2C Knockout cell line (HeLa) Human FCGR2C 1:3~1:6 Negative Online Inquiry
KO33587 FCGR2C Knockout cell line (HCT 116) Human FCGR2C 1:2~1:4 Negative Online Inquiry
KO33588 FCGR2C Knockout cell line (HEK293) Human FCGR2C 1:3~1:6 Negative Online Inquiry
KO33589 FCGR2C Knockout cell line (A549) Human FCGR2C 1:3~1:4 Negative Online Inquiry

Background

FCGR2C Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the FCGR2C gene, which encodes for the Fc gamma receptor IIc (FCGR2C) protein. This receptor plays a critical role in the immune response by mediating interactions between antibodies and immune cells. The knockout cell lines are engineered using CRISPR-Cas9 technology to disrupt the FCGR2C gene, thus allowing researchers to investigate its functional contributions to various biological processes, including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis.

The primary function of these knockout cell lines is to provide a robust platform for elucidating the signaling pathways and cellular responses regulated by FCGR2C. By comparing the knockout lines with wild-type counterparts, researchers can analyze the impact of FCGR2C on immune cell activation, antibody responses, and disease mechanisms, particularly in the context of autoimmune disorders and cancer therapies.

Scientific investigations utilizing FCGR2C knockout cell lines hold immense importance in both basic research and clinical applications. They enable the exploration of therapeutic strategies that can enhance ADCC in immunotherapy, particularly for monoclonal antibody treatments, thereby advancing cancer therapies. Furthermore, insights gleaned from these models can inform the development of novel immunomodulatory drugs targeting the FCGR family of receptors.

One of the unique advantages of our FCGR2C Gene Knockout Cell Lines is their high specificity and reproducibility, providing researchers with consistent results that are critical for translational studies. Compared to traditional methods of gene silencing, these knockout models offer a more definitive approach to understanding gene function, eliminating the ambiguity associated with off-target effects.

The value of our FCGR2C Gene Knockout Cell Lines to researchers and clinicians lies in their ability to streamline the investigation of the immune system's complexities, ultimately contributing to the development of more effective therapies and diagnostics. Our commitment to quality and innovation, backed by extensive expertise in genetic engineering, ensures that our products meet the highest standards for scientific research. Empower your research and clinical pursuits with our expertly crafted FCGR2C Gene Knockout Cell Lines and unlock new insights into immune function and therapeutic interventions.

Please note that all services are for research use only. Not intended for any clinical use.

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