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FBXW8 Knockout Cell Lines

Gene: FBXW8

Official Full Name: F-box and WD repeat domain containing 8provided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02018 FBXW8 Knockout cell line (HeLa) Human FBXW8 1:3~1:6 Negative Online Inquiry
KO02019 FBXW8 Knockout cell line (HCT 116) Human FBXW8 1:2~1:4 Negative Online Inquiry
KO02020 FBXW8 Knockout cell line (HEK293) Human FBXW8 1:3~1:6 Negative Online Inquiry
KO02021 FBXW8 Knockout cell line (A549) Human FBXW8 1:3~1:4 Negative Online Inquiry

Background

FBXW8 Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of the FBXW8 gene's role and its associated pathways in human cellular processes. These specialized cell lines have been engineered to carry a targeted deletion of the FBXW8 gene, enabling researchers to observe the physiological and molecular consequences of its absence. Through precise CRISPR-Cas9 technology, these cell lines create a controlled environment to examine the alterations in cellular functions, protein interactions, and signaling pathways that may occur due to the loss of FBXW8.

The primary function of FBXW8 is to act as a component of the ubiquitin-proteasome system, regulating protein degradation, which plays a crucial role in cellular homeostasis and responses to stress. By utilizing FBXW8 Knockout Cell Lines, researchers can dissect the implications of this regulation in cancer biology, cell cycle dynamics, and various metabolic disorders. These cell lines serve as invaluable models for investigational studies aimed at identifying novel therapeutic targets and understanding underlying pathophysiological mechanisms.

What sets FBXW8 Gene Knockout Cell Lines apart from conventional cell line models is their specificity and the robustness of their performance in experiments. They provide a more accurate representation of the biological effects of FBXW8 loss than traditional knockdown methods, which often retain residual gene expression and function. This increased specificity enhances the reliability of data obtained, offering notable advantages in reproducibility and validation across experiments.

For researchers and clinicians, the ability to study the FBXW8 gene's influence on oncogenesis, response to therapies, and gene regulation mechanisms makes these knockout cell lines invaluable tools in both laboratory and clinical settings. The unique insights gained from using FBXW8 Knockout Cell Lines can lead to the discovery of critical biomarkers and therapeutic strategies.

Our company specializes in delivering high-quality genetic models and is dedicated to advancing scientific research. By providing exceptional products like FBXW8 Gene Knockout Cell Lines, we empower researchers and clinicians to unlock new knowledge and harness the potential for innovative therapies.

Please note that all services are for research use only. Not intended for any clinical use.

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