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FBXO46 Knockout Cell Lines

Gene: FBXO46

Official Full Name: F-box protein 46provided by HGNC

Gene Summary: Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17653 FBXO46 Knockout cell line (HeLa) Human FBXO46 1:3~1:6 Negative Online Inquiry
KO17654 FBXO46 Knockout cell line (HCT 116) Human FBXO46 1:2~1:4 Negative Online Inquiry
KO17655 FBXO46 Knockout cell line (HEK293) Human FBXO46 1:3~1:6 Negative Online Inquiry
KO17656 FBXO46 Knockout cell line (A549) Human FBXO46 1:3~1:4 Negative Online Inquiry

Background

FBXO46 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the functional role of the FBXO46 gene in various biological processes. This product utilizes advanced CRISPR-Cas9 technology to create precise gene knockouts, allowing researchers to analyze the consequences of gene deletion on cellular behavior and signaling pathways.

The key mechanism behind FBXO46 Gene Knockout Cell Lines involves targeted disruption of the FBXO46 gene, which encodes a member of the F-box family of proteins, known to be involved in ubiquitin-mediated proteolysis. This knockout not only promotes an understanding of protein turnover and cellular regulation but also permits the detailed study of associated pathophysiological conditions, providing insights into potential therapeutic avenues.

In both research and clinical settings, these cell lines are invaluable for probing the gene's role in diseases such as cancer and neurodegenerative disorders. Understanding FBXO46 could unveil novel biomarkers for diagnosis or therapeutic targets, thereby facilitating novel treatment strategies. Moreover, their application extends to drug discovery, enabling scientists to test the efficacy of candidates on FBXO46-disrupted cellular systems, enhancing the translational potential of the research.

One of the hallmark advantages of FBXO46 Gene Knockout Cell Lines is their specificity and reproducibility compared to conventional knockdown techniques, which may yield variable results due to incomplete gene silencing. Furthermore, our product comes with a comprehensive user guide and support, enabling researchers to seamlessly integrate our cell lines into their existing workflows.

As a company renowned for our cutting-edge biotechnological solutions, we are committed to advancing scientific discovery through high-quality products. With FBXO46 Gene Knockout Cell Lines, researchers and clinicians are equipped with a powerful tool to deepen their understanding of the FBXO46 gene and its implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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