Gene: FBXO42
Official Full Name: F-box protein 42provided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05856 | FBXO42 Knockout cell line (HeLa) | Human | FBXO42 | 1:3~1:6 | Negative | Online Inquiry |
KO05857 | FBXO42 Knockout cell line (HCT 116) | Human | FBXO42 | 1:2~1:4 | Negative | Online Inquiry |
KO05858 | FBXO42 Knockout cell line (HEK293) | Human | FBXO42 | 1:3~1:6 | Negative | Online Inquiry |
KO05859 | FBXO42 Knockout cell line (A549) | Human | FBXO42 | 1:3~1:4 | Negative | Online Inquiry |
FBXO42 Gene Knockout Cell Lines are specially engineered cellular models that facilitate the study of the FBXO42 gene, which plays a critical role in cellular processes such as protein degradation, cell cycle regulation, and signal transduction. These cell lines have been meticulously designed to yield a complete knockout of the FBXO42 gene, enabling researchers to explore its functional implications, biological pathways, and interactions without the confounding effects of the gene’s expression.
The primary function of FBXO42 Gene Knockout Cell Lines is to provide a platform for investigating how the absence of FBXO42 influences various cellular mechanisms. By employing techniques such as CRISPR/Cas9 gene editing, these cell lines allow for precise alteration of genetic material. This precision enables scientists to conduct in-depth analyses of the pathways affected by FBXO42 and observe the resultant phenotypic changes, thus deepening the understanding of its role in health and disease.
The scientific significance of these cell lines extends to their applications in cancer research, neurobiology, and cellular stress responses, among others. They can serve as valuable tools for drug discovery, helping to identify potential therapeutic targets or biomarkers associated with diseases linked to FBXO42 dysregulation. For clinical settings, insights gained from these models may translate into novel treatment strategies for conditions ranging from cancers to complex genetic disorders.
What sets our FBXO42 Gene Knockout Cell Lines apart from alternatives is their rigorous validation and characterization. Each cell line undergoes comprehensive quality control testing to ensure reliable performance. Additionally, they are compatible with a variety of downstream applications, including RNA sequencing, proteomics, and functional assays, which enhances their versatility.
Researchers and clinicians benefit from these knockout cell lines by gaining access to robust, reproducible models that accurately reflect the absence of FBXO42, thereby driving forward research aims with confidence. Our company’s expertise in genetic engineering and commitment to quality ensures that you receive only the highest standard of biological products, empowering your investigative and clinical needs with unparalleled precision and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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