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FBXO38 Knockout Cell Lines

Gene: FBXO38

Official Full Name: F-box protein 38provided by HGNC

Gene Summary: This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25774 FBXO38 Knockout cell line (HeLa) Human FBXO38 1:3~1:6 Negative Online Inquiry
KO25775 FBXO38 Knockout cell line (HCT 116) Human FBXO38 1:2~1:4 Negative Online Inquiry
KO25776 FBXO38 Knockout cell line (HEK293) Human FBXO38 1:3~1:6 Negative Online Inquiry
KO25777 FBXO38 Knockout cell line (A549) Human FBXO38 1:3~1:4 Negative Online Inquiry

Background

FBXO38 Gene Knockout Cell Lines are specifically engineered cell lines in which the FBXO38 gene has been rendered inactive through targeted genomic editing techniques. The FBXO38 gene, part of the F-box protein family, plays a critical role in cellular processes such as protein ubiquitination and degradation, influencing diverse biological functions from cell cycle regulation to immune responses. The knockout of this gene provides researchers with a powerful tool to study the gene's role in various cellular contexts, as well as the resulting phenotypic changes that may occur due to its loss.

The primary function of FBXO38 Gene Knockout Cell Lines lies in their ability to facilitate the exploration of cellular mechanisms without the confounding influence of the FBXO38 protein. By effectively silencing this gene, researchers can observe the impact on protein turnover pathways and the subsequent effects on cellular health, proliferation, and differentiation. This invaluable information aids in understanding the potential contributions of FBXO38 to diseases, thereby highlighting its significance in biomedical research.

In clinical and research settings, these knockout cell lines serve as a robust platform for drug discovery, toxicology studies, and the development of novel therapies targeting cancer and other diseases linked to dysregulated ubiquitination processes. Compared to traditional methods of gene silencing, such as siRNA or shRNA treatments, the permanent and heritable changes introduced by FBXO38 gene knockout ensure consistent and reliable experimental outcomes over extended periods.

The unique selling points of FBXO38 Gene Knockout Cell Lines include their highly specific disruption of gene function, streamlined application in various experimental models, and the ease of use in both in vitro and in vivo studies. This product empowers researchers and clinicians to obtain critical insights into the molecular underpinnings of various diseases and develop targeted interventions.

At [Your Company Name], we pride ourselves on offering high-quality, genetically engineered cell lines backed by a strong foundation in molecular biology and genetics. Our expertise in gene editing technologies ensures that researchers can rely on our products to drive their experiments, fostering innovation in both academia and industry.

Please note that all services are for research use only. Not intended for any clinical use.

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