Gene: FBXO34
Official Full Name: F-box protein 34provided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17657 | FBXO34 Knockout cell line (HeLa) | Human | FBXO34 | 1:3~1:6 | Negative | Online Inquiry |
KO17658 | FBXO34 Knockout cell line (HCT 116) | Human | FBXO34 | 1:2~1:4 | Negative | Online Inquiry |
KO17659 | FBXO34 Knockout cell line (HEK293) | Human | FBXO34 | 1:3~1:6 | Negative | Online Inquiry |
KO17660 | FBXO34 Knockout cell line (A549) | Human | FBXO34 | 1:3~1:4 | Negative | Online Inquiry |
FBXO34 Gene Knockout Cell Lines represent a powerful tool for genetic research, specifically designed to facilitate studies involving the FBXO34 gene, a member of the F-box protein family involved in ubiquitination processes. These cell lines are engineered using CRISPR-Cas9 technology to create precise gene knockouts, effectively disabling the expression of the FBXO34 protein. This knockout mechanism allows researchers to dissect the functional roles of FBXO34 in cellular processes, particularly those related to cell cycle regulation and oncogenesis.
The primary function of these cell lines is to enable the study of the consequences of FBXO34 gene disruption on various biological pathways. By comparing the knockout cells to their wild-type counterparts, researchers can evaluate the downstream effects on protein stability, cellular signaling, and metabolic processes. This is particularly significant in cancer biology, where the FBXO34 gene has been implicated in tumorigenesis and metastasis. The availability of these knockout lines enhances the ability to elucidate mechanisms of disease, paving the way for the development of targeted therapies.
In terms of scientific importance, FBXO34 Gene Knockout Cell Lines serve as an invaluable asset in both academic and clinical research settings. Their applications extend to drug screening, biomarker discovery, and the investigation of cell viability and proliferation, contributing to a deeper understanding of malignancies associated with FBXO34 deregulation.
These knockout cell lines offer distinct advantages over conventional methods, including enhanced specificity and reproducibility. Researchers can rely on these customized lines for consistent results, reducing variability often observed in transient knockdown approaches. Moreover, their robust nature enables a wide range of applications, from basic research to high-throughput screening efforts.
By incorporating FBXO34 Gene Knockout Cell Lines into your research arsenal, you are not only gaining access to an innovative research tool but also aligning yourself with cutting-edge genetic technology. Our company prides itself on its expertise in developing biologically relevant products that empower researchers and clinicians alike. Through our commitment to quality and scientific integrity, we provide products that drive impactful discoveries in the realm of molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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