Gene: FBXO27
Official Full Name: F-box protein 27provided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27339 | FBXO27 Knockout cell line (HeLa) | Human | FBXO27 | 1:3~1:6 | Negative | Online Inquiry |
KO27340 | FBXO27 Knockout cell line (HCT 116) | Human | FBXO27 | 1:2~1:4 | Negative | Online Inquiry |
KO27341 | FBXO27 Knockout cell line (A549) | Human | FBXO27 | 1:3~1:4 | Negative | Online Inquiry |
FBXO27 Gene Knockout Cell Lines are a sophisticated tool designed for researchers investigating the functional implications of the FBXO27 gene, a member of the F-box protein family known for its role in ubiquitination and proteasome-mediated protein degradation. This product involves the complete gene knockout, ensuring the absence of FBXO27 expression, which allows for in-depth studies into its biological pathways and interactions.
The key function of these knockout cell lines is to facilitate the analysis of FBXO27's role in cellular processes such as cell cycle regulation, signal transduction, and apoptosis. By employing CRISPR-Cas9 technology, these cell lines render the FBXO27 gene non-functional, thereby providing scientists a distinct advantage in understanding how the absence of this gene influences various biological outcomes. This precise gene editing ensures minimal off-target effects, thereby enhancing the reliability of experimental results.
The scientific importance of FBXO27 knockout cell lines extends across multiple research domains, including cancer biology, neurobiology, and developmental genetics. Researchers can utilize these models to explore disease mechanisms, potentially leading to the identification of novel therapeutic targets. In clinical settings, understanding the function of such a gene can also inform biomarker discovery and treatment strategies.
Compared to alternatives, such as transient siRNA knockdowns or overexpressing wild-type genes, our knockout cell lines offer stability and reproducibility, making them ideal for long-term experiments and applications where constant expression of the target gene is crucial. The significant advantage lies in their ability to fully remove the gene's influence, thus providing a clearer picture of its role in physiological and pathological states.
For researchers, the value in using FBXO27 Gene Knockout Cell Lines lies not just in their capacity for detailed functional analysis, but also in the support provided by our knowledgeable team, experienced in cellular and molecular biology. Our company's dedication to delivering high-quality biological products ensures that we meet the precise needs of our users, empowering scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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