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FBXO10 Knockout Cell Lines

Gene: FBXO10

Official Full Name: F-box protein 10provided by HGNC

Gene Summary: Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28162 FBXO10 Knockout cell line (HeLa) Human FBXO10 1:3~1:6 Negative Online Inquiry
KO28163 FBXO10 Knockout cell line (HCT 116) Human FBXO10 1:2~1:4 Negative Online Inquiry
KO28164 FBXO10 Knockout cell line (HEK293) Human FBXO10 1:3~1:6 Negative Online Inquiry
KO28165 FBXO10 Knockout cell line (A549) Human FBXO10 1:3~1:4 Negative Online Inquiry

Background

FBXO10 Gene Knockout Cell Lines are genetically engineered cell lines where the FBXO10 gene has been functionally disrupted, allowing researchers to study the role of this specific gene in various biological processes. The FBXO10 protein is a member of the F-box protein family, which is involved in mediating protein ubiquitination and degradation, crucial for cellular signaling and homeostasis. By utilizing these knockout cell lines, scientists can investigate the downstream effects of FBXO10 loss in pathways related to cancer, cell cycle regulation, and immune responses.

The primary function of the FBXO10 gene knockout is to provide a clear model for assessing changes in cellular behavior attributable to the absence of FBXO10. This mechanism is particularly beneficial for dissecting the role of FBXO10 in disease models, guiding targeted therapies, and understanding its interactions within the ubiquitin-proteasome system. The insights gained from analyzing these cell lines are invaluable for advancing knowledge in fields such as oncology and immunology.

In clinical and research settings, FBXO10 knockout cell lines hold significant importance as they facilitate the identification of novel therapeutic targets and biomarkers. Their application can lead to breakthroughs in personalizing medicine, especially in tumors where FBXO10's regulatory functions are implicated. The unique selling point of our FBXO10 knockout cell lines lies in their high specificity and reliability, ensuring that researchers obtain consistent and replicable results across experiments.

These cell lines represent an essential tool for translational research, enabling users to uncover the complex role of FBXO10 in different biological contexts. By utilizing our products, researchers, and clinicians can accelerate their investigations into gene function, ultimately contributing to the development of more effective therapeutic strategies.

Our company specializes in providing high-quality genetic models and cell line products, underpinned by extensive expertise in molecular biology and genetics. We are committed to supporting the scientific community with innovative solutions that deepen understanding and enhance collaboration in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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