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FBXL15 Knockout Cell Lines

Gene: FBXL15

Official Full Name: F-box and leucine rich repeat protein 15provided by HGNC

Gene Summary: Involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17668 FBXL15 Knockout cell line (HeLa) Human FBXL15 1:3~1:6 Negative Online Inquiry
KO17669 FBXL15 Knockout cell line (HCT 116) Human FBXL15 1:2~1:4 Negative Online Inquiry
KO17670 FBXL15 Knockout cell line (HEK293) Human FBXL15 1:3~1:6 Negative Online Inquiry
KO17671 FBXL15 Knockout cell line (A549) Human FBXL15 1:3~1:4 Negative Online Inquiry

Background

FBXL15 Gene Knockout Cell Lines are a meticulously engineered biological tool designed to facilitate the in-depth study of cellular processes through the targeted inactivation of the FBXL15 gene, which encodes a member of the F-box protein family. This family plays a crucial role in ubiquitin-mediated protein degradation, a key regulatory mechanism in various cellular functions such as cell cycle progression, signal transduction, and apoptosis. By utilizing CRISPR/Cas9 technology, these knockout cell lines ensure precise and efficient gene disruption, allowing researchers to explore the functional consequences of FBXL15 loss within a controlled environment.

The key function of these cell lines lies in their ability to elucidate the biological roles of FBXL15, particularly in cancer research and developmental biology. They serve as ideal models for investigating how FBXL15 deficiency impacts oncogenic pathways, metabolic processes, and cellular responses to stress or drug treatments. By understanding the downstream effects of FBXL15 knockout, researchers can identify potential therapeutic targets and biomarkers, improving the landscape of personalized medicine.

What sets our FBXL15 Gene Knockout Cell Lines apart from alternatives is their high efficiency of gene editing, validated performance in various assay types, and comprehensive characterization. Unlike conventional knockdown approaches, which may leave residual activity, our knockout models provide complete loss-of-function, enabling more robust and reproducible experimental outcomes. This level of precision is essential for generating credible data that informs drug development and other applications in translational research.

For researchers and clinicians seeking to better understand the role of FBXL15 in human health and disease, these knockout cell lines present a valuable resource. They empower researchers to conduct rigorous studies that bridge the gap between basic science and clinical application. With our commitment to providing high-quality, innovative biological products, coupled with extensive expertise in cellular model systems, we strive to support the scientific community in their quest for knowledge and therapeutic discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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