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FANCE Knockout Cell Lines

Gene: FANCE

Official Full Name: FA complementation group Eprovided by HGNC

Gene Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37923 FANCE Knockout cell line (HeLa) Human FANCE 1:3~1:6 Negative Online Inquiry
KO37924 FANCE Knockout cell line (HCT 116) Human FANCE 1:2~1:4 Negative Online Inquiry
KO37925 FANCE Knockout cell line (HEK293) Human FANCE 1:3~1:6 Negative Online Inquiry
KO37926 FANCE Knockout cell line (A549) Human FANCE 1:3~1:4 Negative Online Inquiry

Background

FANCE Gene Knockout Cell Lines represent a cutting-edge innovation in the realm of genetic research, specifically designed to facilitate the functional analysis of the FANCE gene, a crucial component implicated in DNA damage response and repair pathways. These engineered cell lines have undergone gene knockout techniques, removing or disrupting the FANCE gene, thus allowing researchers to investigate its biological roles and pathways in an efficient manner.

The functionality of FANCE Gene Knockout Cell Lines hinges on their ability to mimic loss-of-function scenarios, enabling the study of cellular responses to DNA damage. These cell lines promote a deeper understanding of FANCE's involvement in cellular processes, such as homologous recombination, nucleotide excision repair, and overall genomic stability. Researchers leveraging these tools can uncover potential therapeutic targets for diseases stemming from DNA repair deficiencies, including various cancers.

Scientifically, the importance of FANCE Gene Knockout Cell Lines is underscored by their applications in both fundamental research and clinical settings. By using these knockout models, scientists can explore gene interactions, validate drug targets, and lead preclinical studies aimed at advancing gene therapies and novel cancer treatments.

What sets FANCE Gene Knockout Cell Lines apart from other gene-edited models is their rigorously validated genetic modifications, high reproducibility, and comprehensive support from our expert team. These cells not only save researchers valuable time but also provide exceptional accuracy in assays, enhancing the reliability of experimental outcomes.

For researchers and clinicians engaged in genetic, oncological, or therapeutic research, FANCE Gene Knockout Cell Lines offer invaluable insights into gene function and disease mechanisms. Our company prides itself on providing high-quality biological products and support, ensuring that our customers are equipped with the tools necessary for pioneering discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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