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EZR Knockout Cell Lines

Gene: EZR

Official Full Name: ezrinprovided by HGNC

Gene Summary: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03099 EZR Knockout cell line (HeLa) Human EZR 1:3~1:6 Negative Online Inquiry
KO03100 EZR Knockout cell line (HCT 116) Human EZR 1:2~1:4 Negative Online Inquiry
KO03101 EZR Knockout cell line (HEK293) Human EZR 1:3~1:6 Negative Online Inquiry
KO03102 EZR Knockout cell line (A549) Human EZR 1:3~1:4 Negative Online Inquiry

Background

EZR Gene Knockout Cell Lines are advanced genetic models specifically engineered to permit the precise examination of gene function and regulation in various biological contexts. Utilizing CRISPR-Cas9 technology, these cell lines enable targeted disruptions of specific genes, allowing researchers to study the resulting phenotypic changes and gain insights into the molecular underpinnings of various diseases, including cancer, neurological disorders, and metabolic syndromes.

The primary mechanism of EZR Gene Knockout Cell Lines revolves around the efficient elimination of target gene expression. This is achieved through the formation of double-strand breaks at specific genomic loci, which ultimately leads to non-homologous end joining, a process that frequently introduces small insertions or deletions that disrupt the reading frame of the gene. As a result, researchers can investigate the gene's function more accurately by observing the phenotype of these knockout cells as compared to their wild-type counterparts.

The scientific importance of these cell lines in research settings cannot be overstated. They facilitate significant advancements in functional genomics, drug discovery, and therapeutic development by providing a clearer understanding of gene interactions and pathways. Clinicians can leverage these tools to explore potential targets for new medications or gene therapies, enhancing personalized medicine approaches in treating genetic disorders.

What sets EZR Gene Knockout Cell Lines apart from alternatives is their high efficiency and specificity, coupled with robust validation protocols that ensure minimal off-target effects. Our proprietary designs are optimized for various cell types, offering unparalleled flexibility in experimental setups. Moreover, these cell lines come with extensive support from our expert team, ensuring users can confidently interpret their results and advance their research goals.

As a leader in the field of genetic engineering, our company prides itself on delivering top-tier biological products, such as the EZR Gene Knockout Cell Lines, backed by comprehensive technical support and a commitment to quality. Researchers and clinicians are empowered with our cutting-edge solutions, unlocking new possibilities in gene function studies and therapeutic innovations.

Please note that all services are for research use only. Not intended for any clinical use.

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