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EXPH5 Knockout Cell Lines

Gene: EXPH5

Official Full Name: exophilin 5provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29888 EXPH5 Knockout cell line (HCT 116) Human EXPH5 1:2~1:4 Negative Online Inquiry
KO29889 EXPH5 Knockout cell line (HEK293) Human EXPH5 1:3~1:6 Negative Online Inquiry

Background

EXPH5 Gene Knockout Cell Lines are specialized cellular models engineered to facilitate the investigation of the role of the EXPH5 gene in various biological processes, including cell signaling and membrane dynamics. These cell lines are generated using state-of-the-art CRISPR/Cas9 technology to create precise gene deletions, allowing researchers to explore the implications of EXPH5 disruptions in cellular functions, pathways, and disease states.

The primary function of these knockout cell lines is to provide a robust platform for studying the molecular consequences of EXPH5 deficiency. By eliminating the expression of the EXPH5 protein, these cell lines enable researchers to examine changes in physiological parameters, such as cell proliferation, migration, and apoptosis, providing insights into how EXPH5 contributes to critical cellular events. Furthermore, the resulting phenotypic data can illuminate the gene's role in disease mechanisms, paving the way for potential therapeutic strategies targeting related pathways.

The scientific significance of EXPH5 Gene Knockout Cell Lines lies in their versatility for both basic and applied research. They can be utilized in drug discovery projects, gene therapy development, and investigations into cancer biology, neurodegenerative diseases, and metabolic disorders. Investigators can manipulate these cell lines under controlled laboratory conditions to unravel the functional role of EXPH5, making them essential tools in the field of genetics, molecular biology, and pharmacology.

Distinct from alternative models, the EXPH5 knockout systems offer an unparalleled degree of specificity and reliability due to the precision of the CRISPR technique, reducing the likelihood of off-target effects that can confound experimental results. This reliability ensures that researchers obtain high-quality, reproducible data critical for advancing their studies.

For researchers and clinicians dedicated to understanding complex biological systems and translating findings into therapeutic applications, EXPH5 Gene Knockout Cell Lines represent a significant advancement in experimental tools. They empower the exploration of essential genetic functions and their implications for health and disease.

Our company specializes in providing cutting-edge biological research tools, and our expertise in gene editing technologies ensures that the EXPH5 Gene Knockout Cell Lines are crafted with precision and quality, supporting your research endeavors with confidence and excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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