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EXOC3 Knockout Cell Lines

Gene: EXOC3

Official Full Name: exocyst complex component 3provided by HGNC

Gene Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30967 EXOC3 Knockout cell line (HeLa) Human EXOC3 1:3~1:6 Negative Online Inquiry
KO30968 EXOC3 Knockout cell line (HCT 116) Human EXOC3 1:2~1:4 Negative Online Inquiry
KO30969 EXOC3 Knockout cell line (HEK293) Human EXOC3 1:3~1:6 Negative Online Inquiry
KO30970 EXOC3 Knockout cell line (A549) Human EXOC3 1:3~1:4 Negative Online Inquiry

Background

EXOC3 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed to enable researchers to investigate the functions of the EXOC3 gene, which is implicated in exocytosis and intracellular transport mechanisms. These specialized cell lines are engineered through precise CRISPR-Cas9 gene editing technology to completely disable the EXOC3 gene, allowing for a clearer understanding of its biological roles and the pathways it influences.

The main function of the EXOC3 Gene Knockout Cell Lines is to provide a controlled environment where scientists can study the downstream effects of EXOC3 disruption. By systematically blocking EXOC3, researchers can observe alterations in protein secretion, membrane dynamics, and cellular communication, which are pivotal for understanding various physiological processes as well as the pathophysiology of diseases. The knockout system facilitates comparisons to wild-type cell lines, elucidating not only the functional contributions of EXOC3 but also any compensatory mechanisms that may come into play.

The scientific importance of these cell lines extends to both research and clinical applications, being particularly valuable in studies focused on neurobiology, cancer biology, and metabolic disorders. By employing these knockout models, researchers can explore potential therapeutic targets and better understand the molecular underpinnings of diseases linked to aberrant exocytosis.

Compared to traditional methods of gene manipulation, such as RNA interference, the EXOC3 Gene Knockout Cell Lines offer substantial advantages including permanent gene disruption and consistent phenotypic outcomes across experiments. This stability fosters reproducibility and reliability in experimental results, making them an invaluable resource for biologists aiming for clarity in their findings.

For researchers and clinicians, the value of using EXOC3 Gene Knockout Cell Lines lies in their potential to enhance the understanding of gene functions and their implications in health and disease. By providing a robust platform for exploration, these cell lines facilitate the identification of novel therapeutic strategies and biomarkers.

Our commitment to advancing biological products underscores our dedication to quality and innovation, ensuring that you have reliable tools like the EXOC3 Gene Knockout Cell Lines to help drive your research progress. With expert formulation and support from our team, your exploration into the intricacies of cellular biology is well-equipped for success.

Please note that all services are for research use only. Not intended for any clinical use.

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