Gene: EVL
Official Full Name: Enah/Vasp-likeprovided by HGNC
Gene Summary: Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08698 | EVL Knockout cell line (HeLa) | Human | EVL | 1:3~1:6 | Negative | Online Inquiry |
KO08699 | EVL Knockout cell line (HCT 116) | Human | EVL | 1:2~1:4 | Negative | Online Inquiry |
KO08700 | EVL Knockout cell line (HEK293) | Human | EVL | 1:3~1:6 | Negative | Online Inquiry |
KO08701 | EVL Knockout cell line (A549) | Human | EVL | 1:3~1:4 | Negative | Online Inquiry |
EVL Gene Knockout Cell Lines are sophisticated cellular models engineered to lack the expression of the EVL gene, which encodes an actin-binding protein essential in the regulation of the cytoskeleton and cellular dynamics. Utilizing advanced CRISPR-Cas9 gene editing technology, these cell lines allow for the precise and complete knockout of the EVL gene, thereby providing researchers with a powerful tool to investigate its functional role across various biological processes, including cell motility, adhesion, and signal transduction.
The primary mechanism behind the functionality of EVL Gene Knockout Cell Lines lies in the targeted disruption of the EVL gene, enabling scientists to study the resultant phenotypic changes when the gene is absent. This includes alterations in cell shape, migration patterns, and response to extracellular stimuli. Such insights are critical for understanding the pathophysiology of diseases like cancer, where EVL may play a role in tumor progression and metastasis.
The scientific importance of these cell lines cannot be overstated. They offer unique advantages in both research and clinical settings, allowing for the investigation of gene function in a controlled environment, free from compensatory mechanisms that might mask findings in wild-type cells. Researchers can utilize these knockouts in drug discovery, gene therapy studies, and functional genomics, thereby advancing our understanding of cellular mechanisms and disease states.
What sets EVL Gene Knockout Cell Lines apart from alternative products is their high level of validation and reproducibility. Each line is rigorously characterized to confirm gene deletion and functional integrity, ensuring that researchers obtain reliable and consistent data. Furthermore, our commitment to quality and support means that users have access to detailed technical resources and assistance, enhancing their research experience.
For researchers and clinicians seeking to unravel the complexities of cell biology and disease mechanisms, EVL Gene Knockout Cell Lines provide an invaluable asset. Our company, a leader in the development of genetic and cell-based products, brings extensive expertise in molecular biology and genetic engineering, ensuring that our offerings meet the highest scientific standards and cater to the evolving needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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