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EVC Knockout Cell Lines

Gene: EVC

Official Full Name: EvC ciliary complex subunit 1provided by HGNC

Gene Summary: This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10070 EVC Knockout cell line (HeLa) Human EVC 1:3~1:6 Negative Online Inquiry
KO10071 EVC Knockout cell line (HEK293) Human EVC 1:3~1:6 Negative Online Inquiry
KO10072 EVC Knockout cell line (A549) Human EVC 1:3~1:4 Negative Online Inquiry

Background

EVC Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to possess targeted deletions in the EVC (Ellis-van Creveld) gene. These cell lines serve as a pivotal tool in molecular biology and genetic research, allowing scientists to explore the functional implications of EVC gene deficiency on cellular processes and disease mechanisms. By knocking out specific genes, researchers can create a more controlled experimental environment to study the effects of the EVC gene on cell proliferation, differentiation, and signaling pathways.

The primary function of the EVC Gene Knockout Cell Lines is to provide a reliable platform for examining the phenotypic outcomes associated with EVC gene loss. The mechanism typically involves gene editing technologies, such as CRISPR-Cas9 or homologous recombination, to induce a permanent alteration in the genome. This precise gene targeting allows for the investigation of not only underlying biological pathways but also the pathophysiology of conditions like skeletal dysplasia and congenital anomalies linked to EVC mutations.

In terms of scientific importance, these cell lines have broad applications in both basic and translational research settings. They aid in elucidating the molecular mechanisms of EVC-related diseases, facilitating drug development, and serving as a reference for therapeutic interventions. Additionally, they can be utilized in screening assays to identify potential therapeutic compounds or to validate new hypotheses pertaining to gene interactions.

What sets EVC Gene Knockout Cell Lines apart from other gene-editing tools or cell models is their specificity and ease of use. While traditional methods may require extensive modification or validation, these knockout lines provide an immediate research-ready model with verified gene editing, thus saving valuable time and resources in experimental design.

Researchers and clinicians alike will find immense value in utilizing EVC Gene Knockout Cell Lines for their ability to yield reproducible and relevant data, contributing significantly to our understanding of genetic diseases and their potential treatments. Our company stands at the forefront of gene editing technology, committed to providing high-quality biological products that enhance research capabilities and promote innovation in the field of genomics.

Please note that all services are for research use only. Not intended for any clinical use.

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