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ETS1 Knockout Cell Lines

Gene: ETS1

Official Full Name: ETS proto-oncogene 1, transcription factorprovided by HGNC

Gene Summary: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08873 ETS1 Knockout cell line (HeLa) Human ETS1 1:3~1:6 Negative Online Inquiry
KO08874 ETS1 Knockout cell line (HCT 116) Human ETS1 1:2~1:4 Negative Online Inquiry
KO08875 ETS1 Knockout cell line (HEK293) Human ETS1 1:3~1:6 Negative Online Inquiry
KO08876 ETS1 Knockout cell line (A549) Human ETS1 1:3~1:4 Negative Online Inquiry

Background

ETS1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the roles and functions of the ETS1 gene, a crucial transcription factor involved in various physiological processes, including immune response, cell proliferation, and differentiation. This product utilizes CRISPR-Cas9 gene-editing technology to create precise knockout versions of the ETS1 gene in a selection of cell types, allowing researchers to observe the effects of ETS1 loss on cellular behavior, signaling pathways, and gene expression profiles.

The primary mechanism of action involves the targeted disruption of the ETS1 gene, facilitating comprehensive investigations into its regulatory roles in transcriptional networks. By providing a controlled genetic background, these knockout cell lines enable researchers to dissect the influence of ETS1 in both normal and pathological contexts, thereby enhancing the understanding of its contribution to diseases such as cancer and autoimmune disorders.

In terms of scientific importance, the ETS1 gene knockout cell lines serve as invaluable tools in both basic research and therapeutic development. Their applications range from elucidating molecular mechanisms underlying disease to testing potential therapeutic interventions aimed at restoring normal function to cells exhibiting ETS1 dysregulation.

What sets our ETS1 Gene Knockout Cell Lines apart from competing products is the robust validation of genomic edits, comprehensive characterization of cellular phenotypes, and the availability of multiple cell lines to suit a variety of experimental needs. Additionally, these cell lines are developed in compliance with stringent quality standards to ensure reproducibility and reliability in experimental outcomes.

For researchers and clinicians seeking to deepen their understanding of transcriptional regulation or investigate potential therapeutic targets, the ETS1 Gene Knockout Cell Lines offer unparalleled value. They provide a ready-to-use model system for exploring complex biological phenomena, ultimately driving forward discoveries that may lead to innovative clinical applications.

Our company specializes in the development of high-quality, genetically engineered cell lines that empower researchers to advance their scientific inquiries with confidence. With a commitment to excellence and innovation, we provide tools that facilitate groundbreaking research across multiple fields of biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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