Gene: ESX1
Official Full Name: ESX homeobox 1provided by HGNC
Gene Summary: This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25972 | ESX1 Knockout cell line (HEK293) | Human | ESX1 | 1:3~1:6 | Negative | Online Inquiry |
ESX1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to silence the expression of the ESX1 gene, which plays a critical role in the immune response and tumorigenesis. These cell lines are created using advanced CRISPR-Cas9 technology, allowing for precise edits in the genome, thus enabling researchers to study the functional implications of the ESX1 gene in a controlled environment.
The key functions of ESX1 Gene Knockout Cell Lines revolve around their ability to facilitate in-depth investigations into the role of ESX1 in various biological processes, including immune regulation, cellular stress responses, and cancer progression. By comparing the knockout cell lines to their wild-type counterparts, researchers can elucidate the pathways and molecular mechanisms influenced by ESX1, thereby contributing to a deeper understanding of its significance in health and disease.
The scientific importance of these cell lines is underscored by their applications in fundamental research and clinical studies. They serve as valuable tools for drug discovery, where understanding the ESX1 gene's involvement in disease pathways can assist in identifying novel therapeutic targets. Moreover, they offer insights into immunotherapy strategies, particularly in cancers where ESX1 expression has been linked to poor prognosis.
A distinct advantage of our ESX1 Gene Knockout Cell Lines lies in their ready-to-use format, which streamlines the research process. Unlike other methods that may involve lengthy procedures or variable results, these cell lines provide consistent and reproducible data, enhancing experimental reliability. Furthermore, the use of CRISPR-Cas9 ensures high-efficiency gene editing, significantly reducing off-target effects that can confound biological interpretations.
Researchers and clinicians will find these cell lines invaluable for their potential to enhance experimental accuracy and contribute to groundbreaking discoveries in cancer biology and immunology. The ability to manipulate gene expression with high precision enables a focused approach toward developing innovative therapeutic strategies.
Our company is committed to advancing scientific research through the provision of high-quality, reliable products tailored to meet the demands of the scientific community. With our expertise in genetic engineering and a robust catalog of cutting-edge biological tools, we are here to support your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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