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ERLIN2 Knockout Cell Lines

Gene: ERLIN2

Official Full Name: ER lipid raft associated 2provided by HGNC

Gene Summary: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31151 ERLIN2 Knockout cell line (HeLa) Human ERLIN2 1:3~1:6 Negative Online Inquiry
KO31152 ERLIN2 Knockout cell line (HCT 116) Human ERLIN2 1:2~1:4 Negative Online Inquiry
KO31153 ERLIN2 Knockout cell line (HEK293) Human ERLIN2 1:3~1:6 Negative Online Inquiry
KO31154 ERLIN2 Knockout cell line (A549) Human ERLIN2 1:3~1:4 Negative Online Inquiry

Background

ERLIN2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the ERLIN2 gene, a critical component involved in the regulation of cellular processes such as protein degradation and lipid metabolism. By utilizing CRISPR/Cas9 gene editing technology, ERLIN2 Knockout Cell Lines provide researchers with a powerful tool to study the functional role of ERLIN2 in various biological contexts.

The key mechanism at play within these cell lines involves the perturbation of ERLIN2-associated pathways, enabling insights into signaling cascades that impact cell survival, proliferation, and stress responses. Through the knockout of this gene, scientists can observe altered cellular behaviors and identify downstream effects related to ERLIN2's involvement in disease mechanisms, particularly in metabolic disorders and certain cancers.

This product is of significant importance in both research and clinical settings. In the laboratory, these cell lines facilitate investigations into drug responses and gene function, crucial for drug discovery and development. Clinicians may benefit indirectly by utilizing findings from such studies to develop targeted therapies that exploit the vulnerabilities created by ERLIN2 loss.

What sets ERLIN2 Gene Knockout Cell Lines apart from alternative models is their rigorous validation, providing researchers with confidence in the specificity and reliability of their results. The targeted knockout provides a clear and unambiguous approach to studying gene function, compared to less defined methods such as temporary knockdowns or pharmacological inhibition.

The value of ERLIN2 Gene Knockout Cell Lines extends beyond mere experimentation; they are vital research tools for advancing our understanding of cellular processes and developing therapeutic strategies. By integrating these high-quality cell lines into your research, you can significantly enhance the impact of your work.

Our company specializes in the production of validated gene knockout models, ensuring that researchers can access the highest caliber of biological tools. With a commitment to quality and innovation, we aim to support the scientific community in their quest for discovery and medical advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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