Gene: ERC1
Official Full Name: ELKS/RAB6-interacting/CAST family member 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11084 | ERC1 Knockout cell line (HeLa) | Human | ERC1 | 1:3~1:6 | Negative | Online Inquiry |
KO11085 | ERC1 Knockout cell line (HCT 116) | Human | ERC1 | 1:2~1:4 | Negative | Online Inquiry |
KO11086 | ERC1 Knockout cell line (HEK293) | Human | ERC1 | 1:3~1:6 | Negative | Online Inquiry |
KO11087 | ERC1 Knockout cell line (A549) | Human | ERC1 | 1:3~1:4 | Negative | Online Inquiry |
ERC1 Gene Knockout Cell Lines are a groundbreaking biological tool developed to facilitate the study of the ERC1 gene and its functional roles in cellular processes. These cell lines are engineered through a precise genetic modification technique, enabling researchers to selectively disrupt the ERC1 gene, thereby allowing for the investigation of its contributions to various biological pathways and disease states.
The primary mechanism of these knockout cell lines involves the use of CRISPR-Cas9 technology, which introduces targeted breaks in the genomic DNA at the ERC1 locus. When the cell's natural repair mechanisms attempt to fix these breaks, errors often occur, leading to frame-shifting mutations that deactivate the gene. This strategic disruption allows researchers to study the resulting phenotypic changes in cellular behavior, gene expression, and protein function, providing insights into the gene's role in proliferation, differentiation, and pathogenesis.
The ERC1 Gene Knockout Cell Lines hold significant scientific importance, particularly in the realms of cancer research, neuroscience, and developmental biology. They serve as essential models for elucidating gene function and are instrumental in drug discovery and testing, enabling scientists to assess the therapeutic potential of compounds targeting the ERC1 pathway.
What sets our ERC1 Gene Knockout Cell Lines apart from alternatives is their validated stability and reproducibility, confirmed through rigorous quality control measures. Furthermore, they are available in various relevant cell types, making it easier for researchers to find a model system that best fits their experimental needs. The user-friendly protocols and comprehensive technical support provided enhance the overall user experience, promoting rapid progress in research endeavors.
For researchers and clinicians, the ERC1 Gene Knockout Cell Lines represent a valuable asset that can lead to pioneering findings and contribute to better understanding the complexities of gene function. With a commitment to innovation and scientific advancement, our company stands as a leader in offering high-quality biological products that empower the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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