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EPS15 Knockout Cell Lines

Gene: EPS15

Official Full Name: epidermal growth factor receptor pathway substrate 15provided by HGNC

Gene Summary: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37990 EPS15 Knockout cell line (HeLa) Human EPS15 1:3~1:6 Negative Online Inquiry
KO37991 EPS15 Knockout cell line (HCT 116) Human EPS15 1:2~1:4 Negative Online Inquiry
KO37992 EPS15 Knockout cell line (HEK293) Human EPS15 1:3~1:6 Negative Online Inquiry
KO37993 EPS15 Knockout cell line (A549) Human EPS15 1:3~1:4 Negative Online Inquiry

Background

EPS15 Gene Knockout Cell Lines represent a significant advancement in molecular biology, specifically designed to facilitate the study of endocytic pathways and cellular mechanisms associated with EPS15 protein function. By utilizing CRISPR/Cas9 gene editing technology, these cell lines are meticulously engineered to knock out the EPS15 gene, allowing researchers to explore the consequences of its absence on cellular processes.

The key function of EPS15 is its role in clathrin-mediated endocytosis, a fundamental process involved in the internalization of various molecules and signaling receptors. By disrupting the EPS15 gene, these knockout cell lines provide a powerful platform for investigating the molecular mechanisms of membrane trafficking, signal transduction, and the physiological roles of endocytosis in different cell types. This helps to elucidate how abnormal EPS15 activity may contribute to various pathologies, including cancer and neurodegenerative diseases.

Scientifically, EPS15 Gene Knockout Cell Lines are of immense importance in both research and clinical settings. They serve as valuable tools for drug discovery, enabling scientists to assess the efficacy of therapeutic compounds that target endocytic pathways. Additionally, they can be utilized in studies probing the cellular responses to environmental changes or disease states, thereby broadening the understanding of cellular dynamics and therapeutic strategies.

What sets EPS15 Gene Knockout Cell Lines apart from alternative models is their precision and reliability. The CRISPR/Cas9 methodology ensures high specificity in gene editing, leading to reproducible results that researchers can trust. Moreover, the availability of these cell lines in various relevant cellular backgrounds enhances their applicability across diverse experimental setups.

For researchers and clinicians focused on understanding complex cellular mechanisms, EPS15 Gene Knockout Cell Lines provide unmatched value. They not only streamline experimental workflows but also offer insights that can lead to significant breakthroughs in therapeutic strategies.

Our company prides itself on its dedication to innovation in biological research tools. With a robust expertise in cell line generation and molecular genetics, we are committed to providing researchers with the highest quality products that empower scientific discovery and promote advancements in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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