Gene: EOMES
Official Full Name: eomesoderminprovided by HGNC
Gene Summary: This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34255 | EOMES Knockout cell line (HCT 116) | Human | EOMES | 1:2~1:4 | Negative | Online Inquiry |
KO34256 | EOMES Knockout cell line (HEK293) | Human | EOMES | 1:3~1:6 | Negative | Online Inquiry |
KO34257 | EOMES Knockout cell line (A549) | Human | EOMES | 1:3~1:4 | Negative | Online Inquiry |
EOMES Gene Knockout Cell Lines are genetically engineered models designed to facilitate the study of EOMES (Eomesodermin), a transcription factor crucial for the development and function of immune cells, particularly T cells and natural killer (NK) cells. These cell lines have been meticulously developed using CRISPR/Cas9 technology to achieve precise deletions of the EOMES gene, allowing researchers to investigate the resultant phenotypic and functional consequences in a controlled environment.
The primary function of these EOMES knockout cell lines is to provide a robust platform for analyzing changes in immune response, differentiation pathways, and cellular dynamics. The absence of the EOMES protein allows scientists to elucidate its role in gene expression regulation, cell signaling, and interactions with other transcription factors. This information is pivotal for understanding various aspects of immune function, including cellular maturation and the mechanisms underpinning autoimmune diseases or immunodeficiencies.
Scientifically, Musing EOMES knockout models offers significant applications in both basic research and clinical settings. Researchers can leverage these cell lines to investigate therapeutic targets for immune modulation, develop novel immunotherapies, or study the implications of EOMES in cancer biology. Additionally, these models can enhance the understanding of how EOMES function in diseases characterized by disrupted immune responses, thereby opening avenues for novel therapeutic interventions.
The unique selling points of EOMES Gene Knockout Cell Lines include their high specificity and reproducibility, which significantly mitigate the variability often associated with alternative models. Unlike traditional knockdown approaches, which only reduce EOMES expression, complete knockout ensures the complete absence of the protein, providing clearer insights into its functional roles. Furthermore, these cell lines are easy to use, compatible with high-throughput screening, and can be adapted to various experimental conditions.
For researchers and clinicians, these knockout cell lines represent a valuable tool that can drive forward investigations into fundamental immune mechanisms and therapeutic applications. By acquiring EOMES Gene Knockout Cell Lines, users gain access to a critical resource designed to propel their research and enhance our understanding of immune system dynamics.
With years of expertise in cellular biology and genetic engineering, our company is committed to providing high-quality biological products that empower the scientific community. We ensure that our offerings meet rigorous standards for performance and reliability, enabling researchers to pursue innovative projects with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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