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EMC8 Knockout Cell Lines

Gene: EMC8

Official Full Name: ER membrane protein complex subunit 8provided by HGNC

Gene Summary: Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in Golgi apparatus and endoplasmic reticulum. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00117 EMC8 Knockout cell line (293T) Human EMC8 1:3~1:6 Negative Online Inquiry

Background

EMC8 Gene Knockout Cell Lines represent a cutting-edge tool in the realm of genetic research and functional genomics. These cell lines have been engineered to lack functional EMC8 genes, allowing researchers to investigate the biological roles of EMC8 in cellular processes and disease models. By creating a definitive absence of this gene, scientists can examine the downstream effects of its loss, enabling a more profound understanding of gene function and interaction networks.

Key functions of the EMC8 gene involve its crucial role in the endoplasmic reticulum-associated degradation (ERAD) pathway, which is essential for maintaining cellular homeostasis and protein quality control. The knockout of this gene can elucidate its involvement in various diseases, including neurodegenerative disorders and cancers, by providing insights into how the disruption of protein folding and degradation processes contributes to pathology. Researchers can utilize these cell lines to evaluate drug responses and investigate new therapeutic targets.

The scientific importance of EMC8 Gene Knockout Cell Lines lies in their versatility for both basic and translational research. They can be used in drug discovery, functional assays, and as models to study gene-environment interactions. These cell lines stand out due to their specificity and reliability, making them a superior alternative in comparison to other experimental approaches such as RNA interference, which may lead to off-target effects.

For researchers and clinicians alike, the ability to precisely manipulate gene function via these knockout cell lines represents an invaluable asset. They empower users to delve deeper into the underlying mechanisms of diseases and explore novel avenues for therapeutic intervention. Furthermore, our company boasts a strong track record in producing high-quality biological products, ensuring that users receive not only the best tools for their research but also unparalleled support and expertise in their application.

Please note that all services are for research use only. Not intended for any clinical use.

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