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ELFN1 Knockout Cell Lines

Gene: ELFN1

Official Full Name: extracellular leucine rich repeat and fibronectin type III domain containing 1provided by HGNC

Gene Summary: Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in synapse organization. Predicted to act upstream of or within several processes, including chemical synaptic transmission; synapse assembly; and visual perception. Predicted to be located in dendrite and excitatory synapse. Predicted to be active in several cellular components, including axon terminus; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18036 ELFN1 Knockout cell line (HCT 116) Human ELFN1 1:2~1:4 Negative Online Inquiry

Background

ELFN1 Gene Knockout Cell Lines represent a groundbreaking tool in genetic research, specifically designed to facilitate the study of the roles that the ELFN1 gene plays in neuronal function and development. By utilizing CRISPR-Cas9 technology, these knockout cell lines effectively disable the ELFN1 gene, resulting in a model that allows researchers to observe the resultant phenotypic changes, thereby enhancing understanding of the gene's biological functions and implications in disease.

The primary mechanism of these knockout cell lines involves targeted genome editing, where the CRISPR-Cas9 system introduces double-strand breaks at specific sites within the ELFN1 gene, followed by non-homologous end joining, which leads to insertions or deletions that disrupt gene function. This ability to create precise genetic modifications empowers researchers to investigate the pathways involved in synaptic development and neural circuit formation, as well as potential links to neurodevelopmental disorders.

The scientific importance of ELFN1 Gene Knockout Cell Lines is underscored by their diverse applications in both basic and applied research. They are indispensable in pharmacological studies aimed at discovering novel therapeutic targets for neurological conditions. Moreover, these cell lines can accelerate the pace of research in gene therapy, allowing scientists to explore gene replacement techniques and assess potential treatments for ELFN1-related disorders.

A significant advantage of our ELFN1 Gene Knockout Cell Lines over alternatives is their high efficiency and reproducibility, supported by comprehensive validation protocols. Additionally, they are readily compatible with various in vitro assays, including electrophysiology and calcium imaging, further enhancing their versatility.

These knockout cell lines are particularly valuable to researchers and clinicians who seek to unravel complex genetic networks and their influence on health and disease. By leveraging these tools, users can gain critical insights that may lead to groundbreaking advancements in the understanding of neurological functions.

Backed by years of expertise in molecular biology and a commitment to advancing genetic research, our company offers a range of high-quality biological products, including the ELFN1 Gene Knockout Cell Lines, ensuring that researchers have access to the best resources available for their scientific inquiries.

Please note that all services are for research use only. Not intended for any clinical use.

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