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EHD4 Knockout Cell Lines

Gene: EHD4

Official Full Name: EH domain containing 4provided by HGNC

Gene Summary: Enables cadherin binding activity. Involved in endocytic recycling and protein homooligomerization. Located in endoplasmic reticulum and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26734 EHD4 Knockout cell line (HeLa) Human EHD4 1:3~1:6 Negative Online Inquiry
KO26735 EHD4 Knockout cell line (HCT 116) Human EHD4 1:2~1:4 Negative Online Inquiry
KO26736 EHD4 Knockout cell line (HEK293) Human EHD4 1:3~1:6 Negative Online Inquiry
KO26737 EHD4 Knockout cell line (A549) Human EHD4 1:3~1:4 Negative Online Inquiry

Background

EHD4 Gene Knockout Cell Lines are genetically engineered cellular models that have been utilized to study the functions and regulatory mechanisms associated with the EH domain-containing protein 4 (EHD4), a critical player in the endocytic pathway and cell membrane trafficking. By creating knockout cell lines, researchers have the ability to investigate the absence of EHD4 and its effects on cellular processes, thereby offering insights into the molecular underpinnings of various diseases, including cancer and neurodegenerative disorders.

These cell lines function by employing CRISPR-Cas9 technology to introduce precise mutations in the EHD4 gene, effectively disrupting its expression. This gene knockout allows scientists to analyze alterations in cellular dynamics, including vesicle formation and recycling, which are essential for maintaining cellular homeostasis. The resulting phenotypic changes can be meticulously studied to elucidate the broader implications of uninterrupted endosomal pathways in cellular physiology.

The scientific importance of EHD4 Gene Knockout Cell Lines extends into multiple applications in both research and clinical settings. They serve as invaluable tools for drug discovery, functional genomics, and mechanistic studies, where the role of EHD4 and its associated pathways can be characterized in greater detail. Moreover, these models are instrumental in identifying potential therapeutic targets by elucidating the biological networks involved in human diseases.

One of the distinct advantages of using EHD4 Gene Knockout Cell Lines lies in their specificity and reproducibility, which surpass other gene editing methods like RNA interference. Researchers benefit from the ability to generate knockout models with high efficiency and low off-target effects. Furthermore, our product is optimized for easy manipulation, maintaining robust growth conditions that allow experimental versatility.

Incorporating EHD4 Gene Knockout Cell Lines into your research toolkit is an investment in high-quality biological materials that foster innovative discoveries. Their unique ability to model disease processes with precise genetic disruption empowers researchers and clinicians to navigate complex biological questions.

Our company prides itself on providing advanced genetic tools and resources tailored to the needs of researchers in the life sciences. With a commitment to excellence and scientific integrity, we are dedicated to supporting groundbreaking research initiatives through our innovative product offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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