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EEF1D Knockout Cell Lines

Gene: EEF1D

Official Full Name: eukaryotic translation elongation factor 1 deltaprovided by HGNC

Gene Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38107 EEF1D Knockout cell line (HeLa) Human EEF1D 1:3~1:6 Negative Online Inquiry
KO38108 EEF1D Knockout cell line (HCT 116) Human EEF1D 1:2~1:4 Negative Online Inquiry
KO38109 EEF1D Knockout cell line (HEK293) Human EEF1D 1:3~1:6 Negative Online Inquiry
KO38110 EEF1D Knockout cell line (A549) Human EEF1D 1:3~1:4 Negative Online Inquiry

Background

EEF1D Gene Knockout Cell Lines are specifically engineered cell lines that feature a targeted knockout of the EEF1D gene, which encodes a crucial component of the eukaryotic translation elongation factor complex. This complex plays a vital role in protein synthesis, facilitating the elongation process during translation by delivering aminoacyl-tRNA to the ribosome. As a result, EEF1D is integral to the cellular mechanism of protein production and is involved in regulating various cellular processes, including stress responses and apoptosis.

The EEF1D Gene Knockout Cell Lines function by utilizing CRISPR-Cas9 technology to precisely disrupt the EEF1D gene's coding sequence, ultimately leading to a loss of function. This knockout allows researchers to study the resultant phenotypic effects, such as changes in protein synthesis rates, cellular viability, and stress response pathways. The availability of these cell lines is particularly significant in the context of research into neurodegenerative diseases and cancer, where alterations in translation dynamics have been implicated.

In comparison to alternative methodologies involving non-specific inhibitors or overexpression systems, the EEF1D Gene Knockout Cell Lines present a unique advantage by enabling precise, reproducible, and controlled studies of gene function. They offer a high level of specificity that allows for the exploration of EEF1D's role without the confounding effects often seen with other approaches. This specificity not only amplifies the reliability of experimental results but also accelerates the pace of discovery within translational research.

For researchers and clinicians focusing on the mechanisms of gene regulation, protein synthesis, and its implications in disease models, EEF1D Gene Knockout Cell Lines serve as a powerful tool to dissect cellular functions and to validate therapeutic targets. The potential applications extend beyond academia into pharmaceutical research and development, paving the way for breakthrough interventions.

Our company specializes in providing high-quality biological products tailored for cutting-edge research, with a commitment to precision and innovation. We stand at the forefront of cellular biology advancements, ensuring our customers have access to the tools they need to push the boundaries of science.

Please note that all services are for research use only. Not intended for any clinical use.

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