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EDRF1 Knockout Cell Lines

Gene: EDRF1

Official Full Name: erythroid differentiation regulatory factor 1provided by HGNC

Gene Summary: This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28341 EDRF1 Knockout cell line (HeLa) Human EDRF1 1:3~1:6 Negative Online Inquiry
KO28342 EDRF1 Knockout cell line (HCT 116) Human EDRF1 1:2~1:4 Negative Online Inquiry
KO28343 EDRF1 Knockout cell line (HEK293) Human EDRF1 1:3~1:6 Negative Online Inquiry
KO28344 EDRF1 Knockout cell line (A549) Human EDRF1 1:3~1:4 Negative Online Inquiry

Background

EDRF1 Gene Knockout Cell Lines are genetically modified cell lines in which the EDRF1 gene has been entirely disrupted, allowing researchers to investigate the functional role of this gene in cellular processes such as differentiation, growth, and response to environmental stimuli. These cell lines serve as an invaluable tool for elucidating the signaling pathways and molecular mechanisms regulated by EDRF1, particularly in the context of cardiovascular, neurobiological, and metabolic disorders.

The primary function of the EDRF1 gene involves the production of endothelium-derived relaxing factors that play a critical role in vascular homeostasis. The knockout of this gene enables the study of altered endothelial function in vitro, providing insights into pathophysiological conditions such as hypertension and atherosclerosis. Researchers can utilize these cell lines to explore how the absence of EDRF1 influences nitric oxide production, cellular signaling cascades, and gene expression patterns that are essential for maintaining vascular health.

The scientific importance of EDRF1 Gene Knockout Cell Lines extends into both basic research and clinical applications. In research settings, they facilitate investigations into gene function, gene therapy approaches, and the development of novel therapeutic interventions targeting endothelial dysfunction. Clinically, understanding the role of EDRF1 through these models can lead to potential biomarkers for disease progression and therapeutic targets for cardiovascular diseases.

What sets EDRF1 Gene Knockout Cell Lines apart from alternative models is their specificity and targeted gene disruption, which enhances the reliability of experimental outcomes. Unlike standard wild-type cell lines, these knockout lines offer a robust platform for studying the direct consequences of EDRF1 deficiency, providing clarity that can be often obscured in mixed genetic backgrounds.

The value of EDRF1 Gene Knockout Cell Lines is underscored by their ability to generate reproducible and relevant data that can facilitate the next advancements in biomedical research and therapeutic development. For researchers and clinicians dedicated to understanding vascular biology and its associated diseases, these cell lines are a critical resource that contributes to a deeper understanding of cellular mechanisms.

Our company prides itself on a commitment to excellence in producing high-quality, cutting-edge biological products. With extensive expertise in gene editing technology, we ensure that our EDRF1 Gene Knockout Cell Lines are rigorously validated, empowering our customers to drive forward their research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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