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EDARADD Knockout Cell Lines

Gene: EDARADD

Official Full Name: EDAR associated via death domainprovided by HGNC

Gene Summary: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05190 EDARADD Knockout cell line (HEK293) Human EDARADD 1:3~1:6 Negative Online Inquiry
KO05191 EDARADD Knockout cell line (A549) Human EDARADD 1:3~1:4 Negative Online Inquiry

Background

EDARADD Gene Knockout Cell Lines are a specialized tool in genetic research, specifically designed to facilitate the study of the EDARADD gene's role in various biological processes. These cell lines are genetically modified to completely disrupt the EDARADD gene, which encodes for a key component in the ectodysplasin signaling pathway. This pathway is crucial for the development of ectodermal structures such as hair, teeth, and sweat glands. By providing a model that lacks functional EDARADD protein, researchers can investigate the downstream effects of this gene knockout on cellular behavior, signaling pathways, and phenotypic outcomes.

The primary mechanism of how these cell lines work lies in their ability to provide insights into a range of biological functions associated with ectodermal dysplasia, a condition tied to mutations in EDARADD. In vitro studies utilizing these knockout models enable researchers to dissect the molecular interactions influenced by EDARADD, allowing for a greater understanding of its role in both normal physiology and disease states. Such insights are vital in eliciting the biological ramifications of disrupted signaling pathways, which could lead to therapeutic advancements.

From a scientific perspective, EDARADD Gene Knockout Cell Lines serve as an indispensable resource in developmental biology and genetic research, aiding in both fundamental and translational studies. They provide a robust platform for drug discovery and testing, as well as for the exploration of cell-based therapies aimed at restoring function in ectodermal structures.

What sets our EDARADD Gene Knockout Cell Lines apart from alternatives on the market is their validated knockout efficiency and reproducibility. Additionally, our cell lines come with comprehensive user support and optimized growth conditions, ensuring a seamless integration into existing research protocols.

These cell lines are invaluable to researchers and clinicians looking to deepen their understanding of genetic contributions to ectodermal-related diseases. By facilitating detailed investigation into gene function, they ultimately contribute to the development of innovative treatment strategies.

This product reflects our commitment to advancing biological research, underpinned by our extensive expertise in cell line development and genetic engineering. Our dedication to quality ensures that researchers have access to the most reliable tools necessary for their groundbreaking work.

Please note that all services are for research use only. Not intended for any clinical use.

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