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EBF4 Knockout Cell Lines

Gene: EBF4

Official Full Name: EBF family member 4provided by HGNC

Gene Summary: EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18086 EBF4 Knockout cell line (HCT 116) Human EBF4 1:2~1:4 Negative Online Inquiry
KO18087 EBF4 Knockout cell line (HEK293) Human EBF4 1:3~1:6 Negative Online Inquiry
KO18088 EBF4 Knockout cell line (A549) Human EBF4 1:3~1:4 Negative Online Inquiry

Background

EBF4 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the effects of the EBF4 gene, which plays a crucial role in B-cell development and differentiation. These cell lines have been created using advanced gene editing techniques, such as CRISPR/Cas9, to selectively disable the EBF4 gene, allowing researchers to investigate the functional consequences of its loss. By eliminating EBF4 expression, scientists can elucidate the gene’s molecular pathways, interactions, and overall impact on hematopoiesis and immune responses.

The key functions of EBF4 extend beyond simple gene regulation; it is a transcription factor that influences the expression of numerous downstream target genes critical for cell lineage specification. The EBF4 Gene Knockout Cell Lines serve as a powerful tool in dissecting the biological mechanisms governed by this transcription factor. Through various applications, including gene expression analysis, signal transduction studies, and functional assays, researchers can gain insights into normal and pathological conditions affecting B-cell maturation and related disorders such as lymphomas and leukemias.

The scientific importance of these cell lines is underscored by their potential to facilitate novel therapeutic strategies and the development of targeted treatments in immunology and oncology. Compared to alternative models, EBF4 Gene Knockout Cell Lines offer a more specific, reliable, and reproducible approach to studying gene function in a controlled environment. Their precise editing minimizes off-target effects, ensuring that findings are attributable directly to changes in EBF4 activity.

These cell lines provide significant value to researchers and clinicians aiming to explore the intricacies of immune system modulation, thereby enhancing our understanding of immune-related diseases. The elucidation of EBF4 functions could lead to innovative therapeutic approaches, optimizing patient outcomes in clinical settings.

Our company specializes in the development of high-quality biological tools for research and clinical applications, leveraging cutting-edge technology and rigorous scientific expertise. With EBF4 Gene Knockout Cell Lines, we are committed to advancing the frontiers of biomedical research and providing our partners with exceptional resources that foster breakthrough discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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