Gene: DUSP22
Official Full Name: dual specificity phosphatase 22provided by HGNC
Gene Summary: Enables phosphoprotein phosphatase activity; protein tyrosine kinase binding activity; and protein tyrosine kinase inhibitor activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of T cell receptor signaling pathway; and negative regulation of focal adhesion assembly. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm; leading edge of lamellipodium; and plasma membrane. Part of filamentous actin. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18133 | DUSP22 Knockout cell line (HeLa) | Human | DUSP22 | 1:3~1:6 | Negative | Online Inquiry |
KO18134 | DUSP22 Knockout cell line (HCT 116) | Human | DUSP22 | 1:2~1:4 | Negative | Online Inquiry |
KO18135 | DUSP22 Knockout cell line (HEK293) | Human | DUSP22 | 1:3~1:6 | Negative | Online Inquiry |
KO18136 | DUSP22 Knockout cell line (A549) | Human | DUSP22 | 1:3~1:4 | Negative | Online Inquiry |
DUSP22 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the expression of the Dual Specificity Phosphatase 22 (DUSP22) gene. DUSP22 plays a critical role in regulating key signaling pathways, particularly those related to the immune response and cell proliferation. By effectively knocking out this gene, researchers can investigate the downstream effects on various cellular processes, offering insights into the mechanisms that underlie cellular homeostasis and disease states.
The primary function of these knockout cell lines is to facilitate the exploration of DUSP22's role in mitigating MAPK signaling pathways. Without DUSP22, cells exhibit heightened MAPK activation, which can influence pathways connected to cell growth, differentiation, and apoptosis. This valuable tool enables researchers to assess potential therapeutic targets and elucidate the pathological roles played by aberrant signaling in various conditions, such as cancer and autoimmune disorders.
From a scientific perspective, DUSP22 Gene Knockout Cell Lines hold significant importance as they provide a platform for studying gene function in a controlled environment, enhancing the understanding of gene-associated diseases. Applications in both research and clinical contexts include drug testing, genetic analysis, and the development of targeted therapies.
These cell lines are particularly advantageous over traditional cell models due to their specificity and reliability, which allow for reproducible experiments and higher experimental accuracy. Unlike other genetic models that may have incomplete knockdowns or variable expression, our DUSP22 knockout lines ensure a complete absence of the gene, granting researchers confidence in their results.
For professionals in the fields of molecular biology, oncology, and immunology, DUSP22 Gene Knockout Cell Lines represent a vital resource that can catalyze discoveries and innovations in understanding cellular signaling and pathogenesis. Our company is dedicated to providing premium biological products and resources that meet the highest quality standards, leveraging our extensive expertise in genetic engineering to support groundbreaking research and clinical applications effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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