Gene: DUSP11
Official Full Name: dual specificity phosphatase 11provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34170 | DUSP11 Knockout cell line (HeLa) | Human | DUSP11 | 1:3~1:6 | Negative | Online Inquiry |
KO34171 | DUSP11 Knockout cell line (HCT 116) | Human | DUSP11 | 1:2~1:4 | Negative | Online Inquiry |
KO34172 | DUSP11 Knockout cell line (HEK293) | Human | DUSP11 | 1:3~1:6 | Negative | Online Inquiry |
KO34173 | DUSP11 Knockout cell line (A549) | Human | DUSP11 | 1:3~1:4 | Negative | Online Inquiry |
DUSP11 Gene Knockout Cell Lines are specialized human cell line models engineered to silence or disrupt the expression of the dual specificity phosphatase 11 (DUSP11) gene. These cell lines are invaluable tools in molecular biology that allow researchers to investigate the physiological roles of DUSP11, which is known to regulate key signaling pathways, such as the MAPK pathway. By creating a knockout model, scientists can elucidate the gene's contributions to various cellular processes, including apoptosis, cell proliferation, and differentiation.
The functionality of DUSP11 Gene Knockout Cell Lines lies in their ability to provide a controlled environment where the absence of DUSP11 enables the study of compensatory mechanisms that other genes might invoke. This allows researchers to dissect the signaling cascades activated upon DUSP11 loss and to understand its implications in pathological conditions such as cardiovascular diseases and cancer. The knockout approach is further supported by advanced CRISPR-Cas9 or RNA interference technologies, ensuring precise gene editing and consistent results.
From a scientific standpoint, DUSP11 Gene Knockout Cell Lines hold significant value in translational research, enabling the identification of potential biomarkers and therapeutic targets. Their use in drug discovery and efficacy studies accelerates the development of personalized medicine approaches by exposing vulnerabilities in cancer biology tied to DUSP11 activity.
Compared to conventional cell lines, these knockout models provide a deeper understanding of the specific roles of DUSP11. This specificity enhances experimental reproducibility and reliability, offering researchers a definitive resource for their studies. Their unique gene-editing features ensure researchers are equipped with cutting-edge technologies that yield meaningful insights.
For researchers and clinicians spanning genomics, oncology, and pharmacology, DUSP11 Gene Knockout Cell Lines represent a transformative asset, facilitating innovative research initiatives. Our company specializes in high-quality genetic models and is committed to delivering precise and validated solutions that empower discoveries in the life sciences. By choosing our DUSP11 Gene Knockout Cell Lines, users can confidently advance their research with tools that are rigorously developed and expertly supported.
Please note that all services are for research use only. Not intended for any clinical use.
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