Gene: DRAP1
Official Full Name: DR1 associated protein 1provided by HGNC
Gene Summary: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31692 | DRAP1 Knockout cell line (HeLa) | Human | DRAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO31693 | DRAP1 Knockout cell line (HCT 116) | Human | DRAP1 | 1:2~1:4 | Negative | Online Inquiry |
KO31694 | DRAP1 Knockout cell line (HEK293) | Human | DRAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO31695 | DRAP1 Knockout cell line (A549) | Human | DRAP1 | 1:3~1:4 | Negative | Online Inquiry |
DRAP1 Gene Knockout Cell Lines represent a cutting-edge biological tool designed for advanced genetic research. These cell lines have undergone targeted gene editing to create specific knockout models for the DRAP1 gene, a critical regulator involved in various cellular processes, including apoptosis and cell cycle regulation. By silencing this gene, researchers can effectively study its role in cellular mechanisms, signaling pathways, and disease states, facilitating greater insight into cancer biology, neurodegenerative disorders, and more.
The primary function of DRAP1 Gene Knockout Cell Lines is to enable precise investigations into the physiological and pathological effects of the absence of the DRAP1 protein. Through established methodologies such as CRISPR/Cas9 gene editing, these cell lines offer researchers a robust system to elucidate gene function and its implications in cellular responses. They serve as powerful models to examine drug interactions, gene expression alterations, and pathway activations, ultimately contributing to the discovery of novel therapeutic targets or biomarkers.
In terms of scientific importance, these engineered cell lines find numerous applications in both research and clinical settings. They are invaluable for drug screening and development, allowing researchers to reveal potential efficacy and safety profiles of novel compounds under genetically defined conditions. Furthermore, the ability to mimic specific disease states makes these cell lines essential for translational research aimed at translating laboratory findings into clinical applications.
Compared to traditional cell lines, which may exhibit varying expression levels of target genes, DRAP1 Gene Knockout Cell Lines provide a consistent background, significantly reducing experimental variability. This leads to more reliable and reproducible results, which are crucial for gaining regulatory approval for new therapies. The unique selling point of these knockout models is their capacity to facilitate deeper understanding of the biological consequences of gene loss and their subsequent impact on cellular behavior.
For researchers and clinicians seeking to produce high-quality, reproducible results that advance their understanding of complex biological systems, DRAP1 Gene Knockout Cell Lines represent an essential addition to their toolkit. By employing these specialized cell lines, users can accelerate their research trajectories, uncovering insights that could lead to breakthroughs in medical science and application.
Our company prides itself on its extensive expertise in genetic engineering and development of innovative biological products. We are committed to providing researchers with high-quality tools that empower scientific discovery and enhance the potential for developing transformative therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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