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DPH2 Knockout Cell Lines

Gene: DPH2

Official Full Name: diphthamide biosynthesis 2provided by HGNC

Gene Summary: This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04568 DPH2 Knockout cell line (HeLa) Human DPH2 1:3~1:6 Negative Online Inquiry
KO04569 DPH2 Knockout cell line (HCT 116) Human DPH2 1:2~1:4 Negative Online Inquiry
KO04570 DPH2 Knockout cell line (HEK293) Human DPH2 1:3~1:6 Negative Online Inquiry
KO04571 DPH2 Knockout cell line (A549) Human DPH2 1:3~1:4 Negative Online Inquiry

Background

DPH2 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to investigate the functional role of the DPH2 gene, which is implicated in various biological processes, including ribosomal RNA processing and protein synthesis. This product provides researchers with a powerful tool to elucidate the molecular pathways governed by DPH2 and to explore its potential impact on cell physiology and disease mechanisms.

The key function of DPH2 Gene Knockout Cell Lines is their ability to fully or partially suppress the expression of the DPH2 gene, achieved through the precision of CRISPR-Cas9 technology or similar gene-editing methods. Ensuing assessments in these cell lines can reveal significant alterations in cell growth, differentiation, and response to external stimuli, effectively showcasing the gene's essential contributions to cellular health and function.

In the realm of scientific research and clinical applications, these knockout cell lines are invaluable for investigating disorders linked to dysregulated DPH2 activity, possibly including neurodegenerative diseases and cancers. They facilitate high-throughput screening for drug development, enabling the identification of novel therapeutic targets and aiding in the validation of hypotheses concerning gene function.

What sets DPH2 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. While other methods may induce variable genetic modifications, our knockout lines ensure a consistent and reproducible study environment. This specificity allows for clearer data interpretation, ultimately accelerating the pace of research.

For researchers and clinicians, adopting DPH2 Gene Knockout Cell Lines means gaining insights that could lead to breakthrough discoveries and significant advancements in understanding gene-related diseases. Our commitment to providing high-quality, genetically validated cell lines reflects our expertise in biological products and our dedication to supporting the scientific community with essential tools for research excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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