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DOCK4 Knockout Cell Lines

Gene: DOCK4

Official Full Name: dedicator of cytokinesis 4provided by HGNC

Gene Summary: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08830 DOCK4 Knockout cell line (HeLa) Human DOCK4 1:3~1:6 Negative Online Inquiry
KO08831 DOCK4 Knockout cell line (HCT 116) Human DOCK4 1:2~1:4 Negative Online Inquiry
KO08832 DOCK4 Knockout cell line (HEK293) Human DOCK4 1:3~1:6 Negative Online Inquiry
KO08833 DOCK4 Knockout cell line (A549) Human DOCK4 1:3~1:4 Negative Online Inquiry

Background

DOCK4 Gene Knockout Cell Lines are a sophisticated tool developed for researchers aiming to investigate the functional roles of the DOCK4 gene in cellular processes. The DOCK4 gene encodes a member of the DOCK family of proteins, which are known to be pivotal in regulating cellular signaling pathways, primarily those involved in cytoskeletal dynamics and cell migration. By utilizing CRISPR/Cas9 gene-editing technology, these knockout cell lines enable the precise inactivation of the DOCK4 gene, allowing researchers to dissect the gene's biological functions and its implications in oncogenesis, immune response, and neurodevelopmental disorders.

The key mechanism of action for the DOCK4 knockout cell lines lies in the selective disruption of DOCK4 expression, effectively eliminating its associated protein activity. This allows for the rigorous assessment of downstream effects on cellular behavior, including altered migration patterns and morphology, which are crucial in understanding tumor metastasis and immune cell activation. The ability to create such models provides critical insights into various pathophysiological conditions where DOCK4 may play a significant role.

In the realm of scientific research, the DOCK4 Gene Knockout Cell Lines serve as invaluable resources for elucidating the underlying mechanisms of diseases and for developing potential therapeutic strategies. They offer a significant advantage over traditional knockdown techniques, such as siRNA, by providing stable cell lines that ensure consistent gene knockout, facilitating reproducibility in experiments.

The unique selling points of these cell lines include high specificity and efficiency of the gene knockout along with extensive characterizations that support their applicability across diverse research fields. For researchers, these lines not only streamline experimental workflows but also enhance the reliability of results, leading to robust data applications.

Moreover, the development and offering of the DOCK4 Gene Knockout Cell Lines are backed by our extensive expertise in molecular biology and genetic engineering, ensuring that researchers receive a high-quality product optimized for their experimental needs. Our commitment to advancing biological research through innovative tools positions us as a trusted partner in the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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