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DNTTIP1 Knockout Cell Lines

Gene: DNTTIP1

Official Full Name: deoxynucleotidyltransferase terminal interacting protein 1provided by HGNC

Gene Summary: DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30557 DNTTIP1 Knockout cell line (HeLa) Human DNTTIP1 1:3~1:6 Negative Online Inquiry
KO30558 DNTTIP1 Knockout cell line (HCT 116) Human DNTTIP1 1:2~1:4 Negative Online Inquiry
KO30559 DNTTIP1 Knockout cell line (HEK293) Human DNTTIP1 1:3~1:6 Negative Online Inquiry
KO30560 DNTTIP1 Knockout cell line (A549) Human DNTTIP1 1:3~1:4 Negative Online Inquiry

Background

DNTTIP1 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed to facilitate the study of the DNTTIP1 gene's roles and functions within cellular systems. This product consists of engineered cell lines in which the DNTTIP1 gene has been selectively inactivated through precise CRISPR-Cas9 genome-editing technology. The knockout of this gene allows researchers to investigate the downstream effects on cellular processes, including DNA damage response, transcription regulation, and potentially aberrant cellular pathways associated with diseases.

The key function of DNTTIP1 is its involvement in the processes of DNA repair and stability, making its knockout crucial for evaluating the implications of disrupted genome integrity. By using these cell lines, researchers can elucidate various biological pathways and mechanisms that DNTTIP1 influences, thereby providing insights into cancer biology and therapeutic targets. This is particularly significant in the study of conditions where DNA repair systems are compromised, as DNTTIP1 is implicated in these pathways.

The scientific importance of these cell lines extends to both basic and applied research settings, enabling investigations that can lead to novel interventions in gene therapy and targeted treatments. Compared to wild-type cell lines, DNTTIP1 knockout variants provide a unique platform for dissecting the gene's specific functions, allowing for a finer understanding of cellular responses to drugs and therapies.

What sets DNTTIP1 Gene Knockout Cell Lines apart from other available products is the rigor of the knockout process, validated functionality, and specificity across various experimental paradigms. These features enhance reproducibility and reliability in research, making them a preferred choice among scientists striving to untangle complex biological systems.

For researchers and clinicians, the value of using DNTTIP1 Gene Knockout Cell Lines lies not only in their applicability in functional assays but also in the potential to accelerate discoveries and improve therapeutic strategies in genomic medicine. With our company’s extensive expertise in developing high-quality biological products, we are committed to providing researchers with innovative tools that pave the way for scientific advancements and breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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