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DNER Knockout Cell Lines

Gene: DNER

Official Full Name: delta/notch like EGF repeat containingprovided by HGNC

Gene Summary: Predicted to enable Notch binding activity. Involved in central nervous system development. Located in dendrite; early endosome; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22623 DNER Knockout cell line (HeLa) Human DNER 1:3~1:6 Negative Online Inquiry
KO22624 DNER Knockout cell line (HCT 116) Human DNER 1:2~1:4 Negative Online Inquiry

Background

DNER Gene Knockout Cell Lines are genetically engineered cell lines that have been designed to exclude the expression of the DNER gene, which encodes a membrane protein involved in neural differentiation and signaling processes. By knocking out this specific gene, researchers can investigate its functional role in various biological contexts, including neuronal development, cellular signaling pathways, and neurological diseases.

The mechanism through which DNER Gene Knockout Cell Lines operate involves using established genetic engineering techniques, such as CRISPR-Cas9 or RNA interference, to introduce specific mutations or deletions in the DNER gene. This targeted approach allows for the precise study of gene function and its implications on cell behavior, enabling scientists to observe phenotypic changes that occur in the absence of DNER expression. Additionally, these cell lines serve as valuable models to explore molecular interactions and the downstream effects of DNER signaling on cellular processes.

The scientific importance of DNER Gene Knockout Cell Lines extends to fields like neurobiology and regenerative medicine. They can be used to model neurodegenerative diseases, understand synaptic plasticity, and assess potential therapeutic responses to DNER-related pathologies. In clinical research settings, these models provide a crucial platform for drug discovery and validation, making them instrumental in translating basic research findings into clinical applications.

What sets our DNER Gene Knockout Cell Lines apart from alternatives in the market is their rigorous validation and consistent performance across different experimental conditions. These lines are genetically homogeneous, ensuring reliable replicates in experiments, and are provided with detailed characterization data, allowing users to focus on their research without worrying about variability.

For researchers and clinicians alike, DNER Gene Knockout Cell Lines offer an invaluable tool to delve deeper into the complexities of neural signaling and its implications in health and disease. By leveraging our robust product offerings and expertise in genetic engineering, our company is committed to empowering scientific advancements, ensuring that our customers have access to top-tier biological products that drive innovation and discovery in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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