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DNASE2 Knockout Cell Lines

Gene: DNASE2

Official Full Name: deoxyribonuclease 2, lysosomalprovided by HGNC

Gene Summary: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03942 DNASE2 Knockout cell line (HeLa) Human DNASE2 1:3~1:6 Negative Online Inquiry
KO03943 DNASE2 Knockout cell line (HCT 116) Human DNASE2 1:2~1:4 Negative Online Inquiry
KO03944 DNASE2 Knockout cell line (HEK293) Human DNASE2 1:3~1:6 Negative Online Inquiry
KO03945 DNASE2 Knockout cell line (A549) Human DNASE2 1:3~1:4 Negative Online Inquiry

Background

DNASE2 Gene Knockout Cell Lines are a sophisticated tool engineered to specifically disrupt the DNASE2 gene, which encodes a critical enzyme involved in DNA catabolism during biological processes such as apoptosis and inflammation. These cell lines serve as invaluable models for investigating the biological functions of DNASE2, as well as its role in diseases where DNA degradation is pivotal, including certain cancers and autoimmune disorders.

The key mechanism by which these knockout cell lines operate is through the loss of function of DNASE2, allowing researchers to observe the resultant cellular behaviors, such as altered apoptosis rates and modified inflammatory responses. This specific gene disruption aids in elucidating the pathways that depend on DNASE2 activity, providing insights into intracellular DNA handling and its implications in disease mechanisms.

Scientifically, the importance of DNASE2 Gene Knockout Cell Lines is underscored by their applications in both research and clinical settings. They enable the study of autoinflammatory diseases, provide models for drug testing, and offer platforms for understanding apoptosis in cancer therapies. By utilizing CRISPR/Cas9 technology for precise editing, they ensure reproducibility in experimental results, making them essential for rigorous scientific inquiries.

What sets DNASE2 Gene Knockout Cell Lines apart from alternative models is their targeted approach and specificity. Unlike broad-spectrum knockout strategies, these lines allow researchers to focus explicitly on the effect of DNASE2 deficiency without confounding variables, promoting clearer interpretations of experimental data.

The value of this product lies in its ability to advance biomedical research, providing researchers and clinicians with the capability to dissect complex biological phenomena. By utilizing DNASE2 Gene Knockout Cell Lines, scientists can accelerate the discovery of therapeutic targets and inform clinical strategies in treating disorders linked to DNASE2 dysfunction.

Our company leverages cutting-edge gene editing technologies and extensive expertise in molecular biology to deliver high-quality biological products, like the DNASE2 Gene Knockout Cell Lines, designed to meet the rigorous demands of today’s biomedical research landscape.

Please note that all services are for research use only. Not intended for any clinical use.

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