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DNASE1L2 Knockout Cell Lines

Gene: DNASE1L2

Official Full Name: deoxyribonuclease 1 like 2provided by HGNC

Gene Summary: Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to act upstream of or within corneocyte development and hair follicle development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38208 DNASE1L2 Knockout cell line (HeLa) Human DNASE1L2 1:3~1:6 Negative Online Inquiry
KO38209 DNASE1L2 Knockout cell line (HEK293) Human DNASE1L2 1:3~1:6 Negative Online Inquiry

Background

DNASE1L2 Gene Knockout Cell Lines represent a pivotal advancement in the field of molecular biology, designed to facilitate the comprehensive study of the DNASE1L2 gene and its associated pathways. These cell lines have been genetically engineered to disrupt the DNASE1L2 gene, allowing researchers to investigate the gene's role in nucleic acid metabolism, inflammation, and immune response. By systematically eliminating the genetic function of DNASE1L2, scientists can better understand its implications in various diseases, including autoimmune disorders and cancer.

The primary mechanism through which DNASE1L2 influences cellular processes involves the regulation of extracellular DNA levels. This regulation is crucial not only for maintaining cellular homeostasis but also for modulating immune responses. The knockout of DNASE1L2 can lead to dysregulated DNA accumulation in the extracellular environment, which may trigger significant inflammatory responses and potentially elucidate mechanisms underlying certain pathophysiological conditions.

In scientific and clinical research settings, the application of DNASE1L2 Gene Knockout Cell Lines is invaluable. They serve as a robust tool for elucidating the functional consequences of DNASE1L2 loss, enabling the exploration of novel therapeutic strategies aimed at targeting its pathways. Additionally, these cell lines can facilitate drug screening processes, providing insight into how inhibitors of DNASE1L2 may alter disease outcomes.

What sets DNASE1L2 Gene Knockout Cell Lines apart from alternative products is their precision and reliability; they are generated using state-of-the-art CRISPR-Cas9 technology, ensuring high efficiency and specificity in gene editing. This innovative approach maximizes the probability of successful knockout, thereby increasing the likelihood of reproducible results.

For researchers and clinicians dedicated to advancing our understanding of DNA metabolism and immune regulation, DNASE1L2 Gene Knockout Cell Lines offer unparalleled value. By employing this tool, users gain access to a deeper understanding of therapeutic targets and the potential for novel interventions.

Our company brings years of expertise in genetic engineering and cell line development, ensuring that our products meet the highest standards of quality and innovation. By choosing our DNASE1L2 Gene Knockout Cell Lines, researchers are not only investing in premium scientific tools but are also partnering with a leader in biological product development committed to enhancing research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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