Gene: DNAJC6
Official Full Name: DnaJ heat shock protein family (Hsp40) member C6provided by HGNC
Gene Summary: DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32688 | DNAJC6 Knockout cell line (HeLa) | Human | DNAJC6 | 1:3~1:6 | Negative | Online Inquiry |
KO32689 | DNAJC6 Knockout cell line (HCT 116) | Human | DNAJC6 | 1:2~1:4 | Negative | Online Inquiry |
KO32690 | DNAJC6 Knockout cell line (HEK293) | Human | DNAJC6 | 1:3~1:6 | Negative | Online Inquiry |
KO32691 | DNAJC6 Knockout cell line (A549) | Human | DNAJC6 | 1:3~1:4 | Negative | Online Inquiry |
DNAJC6 Gene Knockout Cell Lines represent a pioneering advancement in the study of gene function and its implications in various biological processes. These engineered cell lines are specifically designed to have a targeted knockout of the DNAJC6 gene, which encodes a chaperone protein involved in neuronal function and endosomal trafficking. This product serves as a crucial tool for researchers aiming to investigate the role of DNAJC6 in cellular mechanisms and its potential links to neurodegenerative disorders, including Parkinson's disease.
The key function of DNAJC6 gene knockout cell lines lies in their ability to provide insights into the cellular pathways disrupted by the absence of this gene. This mechanism allows for the detailed study of how DNAJC6 contributes to the regulation of synaptic vesicle cycling and the maintenance of neuronal health. Researchers can utilize these knockout models to perform functional assays, evaluate gene interaction networks, and assess the impact of potential therapeutic interventions.
The scientific importance of DNAJC6 knockout cell lines cannot be overstated. They enable the dissection of complex cellular dynamics in both academic and clinical research settings, fostering advancements in our understanding of neurobiology and pathophysiology. These cell lines also facilitate the screening of pharmacological compounds and the development of innovative therapeutic strategies to combat neurodegenerative diseases.
Compared to conventional models, DNAJC6 gene knockout cell lines offer unique advantages, including precise gene editing, reproducibility, and the ability to recapitulate human disease processes more accurately. These features make them a superior choice for researchers seeking reliable and relevant experimental models.
For researchers and clinicians alike, the value of DNAJC6 gene knockout cell lines lies in their ability to provide invaluable data, driving forward the quest for therapeutic solutions and enhancing the understanding of gene-function relationships. Our company specializes in the creation of high-quality biological products, leveraging advanced gene-editing technologies to support scientific excellence and innovation in the field of molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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