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DNAJC18 Knockout Cell Lines

Gene: DNAJC18

Official Full Name: DnaJ heat shock protein family (Hsp40) member C18provided by HGNC

Gene Summary: Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36929 DNAJC18 Knockout cell line (HeLa) Human DNAJC18 1:3~1:6 Negative Online Inquiry
KO36930 DNAJC18 Knockout cell line (HCT 116) Human DNAJC18 1:2~1:4 Negative Online Inquiry
KO36931 DNAJC18 Knockout cell line (HEK293) Human DNAJC18 1:3~1:6 Negative Online Inquiry
KO36932 DNAJC18 Knockout cell line (A549) Human DNAJC18 1:3~1:4 Negative Online Inquiry

Background

DNAJC18 gene knockout cell lines are engineered cellular models designed to elucidate the biological functions of the DNAJC18 gene, which is implicated in crucial cellular processes, including protein folding and mitochondrial homeostasis. By systematically knocking out this gene, researchers can investigate the downstream effects on cellular physiology, providing valuable insight into gene function and associated pathways.

These cell lines utilize CRISPR/Cas9 technology for precise gene editing, ensuring that the deletion of DNAJC18 is both efficient and reproducible. The absence of this gene allows researchers to study its role in cellular stress responses, neurodegenerative diseases, and other conditions linked to mitochondrial dysfunction. This knockout model is particularly vital for testing hypotheses related to the pathophysiology of diseases where DNAJC18 is believed to be a crucial player, thereby opening avenues for targeted therapeutic interventions.

The scientific importance of DNAJC18 knockout cell lines lies in their applications in both fundamental research and translational medicine. These models enable investigators to evaluate cellular responses to stress, evaluate drug efficacy, and understand the molecular underpinnings of diseases at a cellular level, significantly enhancing our understanding of various biological systems.

Compared to conventional cell lines, these knockout models provide a unique advantage by enabling the study of protein function in a controlled environment where the variable of the target gene is effectively removed. This specificity is crucial for obtaining clear, unambiguous data, making it easier to correlate findings with phenotypic outcomes.

For researchers and clinicians, the DNAJC18 gene knockout cell lines offer invaluable resources for advancing knowledge in mitochondrial biology and cellular response mechanisms, making them an essential tool for modern laboratories focused on cutting-edge biological research. Our company prides itself on delivering high-quality, precise biological products, backed by extensive expertise in gene editing technologies and cell line development, positioning us as a trusted partner in your scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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