Home / DISC1 Knockout Cell Lines

DISC1 Knockout Cell Lines

Gene: DISC1

Official Full Name: DISC1 scaffold proteinprovided by HGNC

Gene Summary: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27760 DISC1 Knockout cell line (HEK293) Human DISC1 1:3~1:6 Negative Online Inquiry

Background

DISC1 Gene Knockout Cell Lines are genetically engineered cell models wherein the Disrupted-In-Schizophrenia 1 (DISC1) gene has been knocked out, offering an essential tool for studying the molecular mechanisms underlying psychiatric disorders, particularly schizophrenia. These cell lines facilitate the investigation of the functional role of DISC1 in neuronal development, synaptic signaling, and various pathways implicated in mental health conditions.

The primary function of these knockout cell lines hinges on the absence of the DISC1 protein, which plays a crucial role in neurodevelopment and neurotransmission. By eliminating DISC1 expression, researchers can observe resultant phenotypic changes, assess cellular signaling pathways, and elucidate the gene's involvement in various psychiatric disorders. This mechanistic understanding is invaluable for identifying potential therapeutic targets.

In both research and clinical settings, DISC1 Gene Knockout Cell Lines provide a unique platform for high-throughput screening of pharmacological agents and genetic modifiers that may ameliorate the negative impacts of DISC1 disruption. The scientific community has recognized the importance of these cell lines as they mirror critical aspects of neuropsychiatric disease, thereby enhancing the translational potential of findings derived from such studies.

What sets our DISC1 Gene Knockout Cell Lines apart from alternatives is their rigorously validated genetic integrity and functional relevance to human biology. Our proprietary technology ensures precise gene editing, resulting in reliable and reproducible models that can significantly accelerate the pace of research compared to less specific or non-genetically defined alternatives.

For researchers and clinicians aiming to deepen their understanding of schizophrenia and related disorders, our DISC1 Gene Knockout Cell Lines represent an invaluable resource. Their ability to model disease-relevant pathways and facilitate drug discovery initiatives equips users with a robust platform for developing innovative treatment strategies.

Our company specializes in providing cutting-edge biological products that meet the highest standards of quality and efficacy, empowering researchers and clinicians in the pursuit of groundbreaking discoveries in mental health.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.