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DEK Knockout Cell Lines

Gene: DEK

Official Full Name: DEK proto-oncogeneprovided by HGNC

Gene Summary: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34400 DEK Knockout cell line (HeLa) Human DEK 1:3~1:6 Negative Online Inquiry
KO34401 DEK Knockout cell line (HCT 116) Human DEK 1:2~1:4 Negative Online Inquiry
KO34402 DEK Knockout cell line (HEK293) Human DEK 1:3~1:6 Negative Online Inquiry
KO34403 DEK Knockout cell line (A549) Human DEK 1:3~1:4 Negative Online Inquiry

Background

DEK Gene Knockout Cell Lines are meticulously engineered cellular models wherein the DEK gene has been selectively disrupted, providing invaluable tools for studying gene function and cellular mechanisms. These cell lines facilitate the investigation of DEK's role in various biological processes, including gene regulation, chromatin structure, and apoptosis, by enabling researchers to observe the cellular responses in a controlled environment devoid of DEK expression.

The functionality of DEK Gene Knockout Cell Lines is rooted in gene editing technologies, typically employing CRISPR-Cas9 methodologies. This precise genome-editing approach allows for the targeted removal of the DEK gene, thereby elucidating its contributions to pathways implicated in oncogenesis, cell proliferation, and stress responses. By comparing mutant lines to their wild-type counterparts, researchers can derive insights into differential cellular behavior and gene interactions.

Scientifically, these knockout cell lines have vast applications in both research and clinical contexts. They are instrumental in understanding cancer biology, given DEK's association with various malignancies. Moreover, these models serve as platforms for drug screening and therapeutic development, enhancing the potential for translational research.

What sets DEK Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. The rigorous validation processes ensure that the resulting lines are consistent and reproducible, delivering high-quality data to researchers. This precision minimizes off-target effects and facilitates the execution of downstream applications, such as functional assays and molecular characterizations.

For researchers and clinicians invested in exploring the fundamental aspects of gene function or developing targeted treatments for DEK-associated diseases, these cell lines represent a critical asset. Their ability to provide clarity in gene function studies enhances the efficiency of research initiatives, ultimately propelling advancements in genetic therapies.

With a commitment to scientific excellence, our company specializes in the development and procurement of high-quality biological products, ensuring that our customers have access to state-of-the-art tools for their research endeavors. We strive to support the scientific community in unraveling complex biological questions and translating findings into clinical innovations.

Please note that all services are for research use only. Not intended for any clinical use.

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