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DDX50 Knockout Cell Lines

Gene: DDX50

Official Full Name: DExD-box helicase 50provided by HGNC

Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18351 DDX50 Knockout cell line (HeLa) Human DDX50 1:3~1:6 Negative Online Inquiry
KO18352 DDX50 Knockout cell line (HCT 116) Human DDX50 1:2~1:4 Negative Online Inquiry
KO18353 DDX50 Knockout cell line (HEK293) Human DDX50 1:3~1:6 Negative Online Inquiry
KO18354 DDX50 Knockout cell line (A549) Human DDX50 1:3~1:4 Negative Online Inquiry

Background

DDX50 Gene Knockout Cell Lines represent a cutting-edge tool for researchers committed to unraveling the complexities of RNA processing and gene regulation. These cell lines have been genetically modified to specifically disrupt the DDX50 gene, known for its role in RNA helicase activity. By introducing targeted gene deletions, these knockout cell lines facilitate the unambiguous study of DDX50's function in various cellular processes, including mRNA metabolism, stress responses, and translational control.

The primary function of the DDX50 knockout cell lines lies in their ability to provide researchers with a robust platform to investigate the downstream effects of DDX50 deficiency. Mechanistically, the absence of the DDX50 protein alters the dynamics of RNA interactions and can significantly impact gene expression profiles. This information is critical, as DDX50 has been implicated in various diseases, including cancer, highlighting its importance as a potential therapeutic target.

In research and clinical settings, DDX50 knockout cell lines serve as indispensable tools for elucidating gene function, screening for potential drug candidates, and studying disease mechanisms. These models allow for high-throughput analyses and targeted investigations, enabling researchers to draw more precise conclusions about the role of DDX50 in cellular behavior and pathology.

One of the key advantages of using DDX50 knockout cell lines is their precision and reliability. Unlike alternative methods, such as RNA interference, which can produce off-target effects, these knockout lines provide a definitive genetic background. This specificity ensures that results are more reproducible and that interpretations regarding gene function are sound.

For researchers, clinicians, and biotechnology companies seeking to advance our understanding of gene function and its implications in health and disease, DDX50 Gene Knockout Cell Lines offer invaluable insights. Their ability to facilitate targeted research endeavors positions them as a vital resource in the molecular biology toolkit.

Our company specializes in the development of high-quality genetic models, and our deep expertise in gene editing ensures that DDX50 knockout cell lines meet the stringent standards required for cutting-edge research. By choosing our product, you gain access to reliable tools that will significantly enhance your scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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