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DCN Knockout Cell Lines

Gene: DCN

Official Full Name: decorinprovided by HGNC

Gene Summary: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11568 DCN Knockout cell line (HeLa) Human DCN 1:3~1:6 Negative Online Inquiry

Background

DCN Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology designed to facilitate the study of gene function and the underlying mechanisms of various biological processes. These cell lines are engineered to have specific genes, particularly the decorin (DCN) gene, inactivated or "knocked out," allowing researchers to observe the resultant phenotypic changes and cellular behaviors that occur in its absence. This targeted disruption is achieved through advanced genome editing techniques, such as CRISPR-Cas9, which ensures high precision and efficiency in gene modification.

The primary function of DCN Gene Knockout Cell Lines lies in their ability to elucidate the role of decorin in cell signaling, extracellular matrix organization, and tissue homeostasis. By analyzing these knockout models, scientists can investigate how loss of decorin impacts cellular proliferation, adhesion, differentiation, and response to various stimuli, particularly in the context of cancer and fibrosis. Such insights are crucial for understanding disease mechanisms and developing therapeutic strategies.

In both research and clinical settings, DCN Gene Knockout Cell Lines hold significant value by serving as powerful experimental platforms to validate new drug targets or to assess the efficacy of therapeutic interventions. Their application can enhance translational research and assist in the identification of biomarkers for disease diagnostics.

Compared to traditional methods of gene silencing, such as RNA interference (RNAi), DCN Gene Knockout Cell Lines provide a more stable and permanent form of gene inactivation, eliminating the variability associated with transient knockdowns. This offers a more accurate reflection of the gene's role over time.

For researchers and clinicians, the availability of DCN Gene Knockout Cell Lines signifies an invaluable resource that accelerates scientific discovery and fosters innovation. Our company, with its dedication to excellence in biological products, brings these expertly validated cell lines to the forefront of genetic research, supporting your pursuit of meaningful advancements in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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