Home / DCLK1 Knockout Cell Lines

DCLK1 Knockout Cell Lines

Gene: DCLK1

Official Full Name: doublecortin like kinase 1provided by HGNC

Gene Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33456 DCLK1 Knockout cell line (HEK293) Human DCLK1 1:3~1:6 Negative Online Inquiry

Background

DCLK1 Gene Knockout Cell Lines are specialized cellular models designed for the functional analysis of the Doublecortin-Like Kinase 1 (DCLK1) gene, which has been implicated in various physiological and pathological processes, including neurogenesis and tumorigenesis. These cell lines are generated using CRISPR/Cas9 gene-editing technology, ensuring precise and efficient disruption of the DCLK1 gene, enabling researchers to investigate the gene's role in cellular signaling, differentiation, and disease progression.

The primary function of DCLK1 Gene Knockout Cell Lines is to facilitate the study of the genetic and molecular pathways that DCLK1 modulates in diverse biological contexts. By eliminating DCLK1 expression, researchers can observe the downstream effects on cellular behavior, gene expression, and metabolic processes. This enables the delineation of the gene's contributions to cancer development, neurological disorders, and other diseases, providing critical insights into potential therapeutic targets.

The scientific importance of these knockout cell lines cannot be overstated; they serve as powerful tools in both research and clinical settings. In laboratories, they enable rigorous functional studies and drug screening assays, while in clinical environments, they may assist in the validation of therapeutic strategies that target the DCLK1 pathway. Compared to traditional gene silencing methods, such as RNA interference, gene knockout through CRISPR technologies offers a more permanent and complete alteration of gene expression, resulting in more reliable experimental outcomes.

One of the unique selling points of our DCLK1 Gene Knockout Cell Lines is the high efficiency of the gene-editing process, complemented by robust characterization to confirm successful knockout and cellular stability. Additionally, our product provides exceptional reproducibility and consistency across experiments, bolstering the reliability of research findings.

For researchers and clinicians, these cell lines represent a valuable asset for advancing knowledge in cancer biology and neuroscience, potentially leading to innovative treatments and enhanced understanding of disease mechanisms. Our company prides itself on its commitment to quality and scientific excellence, having a robust portfolio of biological products that empower research across diverse fields. With our DCLK1 Gene Knockout Cell Lines, you can be confident in your pursuit of groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.