Gene: DCAF12
Official Full Name: DDB1 and CUL4 associated factor 12provided by HGNC
Gene Summary: This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02751 | DCAF12 Knockout cell line (HeLa) | Human | DCAF12 | 1:3~1:6 | Negative | Online Inquiry |
KO02752 | DCAF12 Knockout cell line (HCT 116) | Human | DCAF12 | 1:2~1:4 | Negative | Online Inquiry |
KO02753 | DCAF12 Knockout cell line (HEK293) | Human | DCAF12 | 1:3~1:6 | Negative | Online Inquiry |
KO02754 | DCAF12 Knockout cell line (A549) | Human | DCAF12 | 1:3~1:4 | Negative | Online Inquiry |
DCAF12 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to effectively disable the DCAF12 gene, a key player in regulating various cellular processes including cell cycle progression and protein homeostasis. These knockout cell lines are critical tools for scientists aiming to understand the implications of DCAF12 deletion on cellular functions and corresponding biological pathways.
The primary function of these cell lines lies in their ability to facilitate research into the consequences of DCAF12 genotype changes, shedding light on its role in cellular stress responses, apoptosis, and oncogenic processes. By removing the DCAF12 gene, researchers can investigate the downstream effects on protein degradation pathways, particularly those associated with the ubiquitin-proteasome system, and contribute to the understanding of various diseases, including cancer and neurodegenerative disorders.
The scientific importance of DCAF12 Gene Knockout Cell Lines is underscored by their diverse applications in both research and clinical settings. They are invaluable for drug discovery, gene function studies, and understanding disease mechanisms. Additionally, they serve as robust models for developing targeted therapeutics that seek to disrupt the functions of pathologically overactive proteins, thereby presenting avenues for innovative treatment strategies.
Compared to alternative knockout models, the DCAF12 Gene Knockout Cell Lines are designed with precision genome-editing techniques, ensuring higher specificity and efficiency. They come with built-in validation through next-generation sequencing, eliminating concerns associated with off-target effects typically seen in traditional knockout approaches. This enhances researcher confidence in reproducibility and reliability of experimental results.
Researchers and clinicians will find DCAF12 Gene Knockout Cell Lines to be an essential asset to their laboratories as they facilitate insightful discoveries that could lead to groundbreaking advancements in biotechnology and therapeutic interventions. The use of these cell lines can translate into significant efficiency gains in experimental workflows.
Our company prides itself on its expertise in genetic engineering and cell line development, ensuring that our customers receive high-quality biological products that meet rigorous scientific standards. With our ongoing commitment to innovative research solutions, we support the scientific community in making strides towards enhanced understanding and treatment of complex biological issues.
Please note that all services are for research use only. Not intended for any clinical use.
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