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DBNL Knockout Cell Lines

Gene: DBNL

Official Full Name: drebrin likeprovided by HGNC

Gene Summary: Enables cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27242 DBNL Knockout cell line (HeLa) Human DBNL 1:3~1:6 Negative Online Inquiry
KO27243 DBNL Knockout cell line (HCT 116) Human DBNL 1:2~1:4 Negative Online Inquiry
KO27244 DBNL Knockout cell line (HEK293) Human DBNL 1:3~1:6 Negative Online Inquiry
KO27245 DBNL Knockout cell line (A549) Human DBNL 1:3~1:4 Negative Online Inquiry

Background

DBNL Gene Knockout Cell Lines are a suite of genetically modified cell lines designed specifically for the study of the DBNL gene, which encodes a protein involved in actin filament dynamics and cellular signaling. These knockout cell lines facilitate the comprehensive investigation of DBNL's biological roles by providing a controlled environment devoid of its expression, allowing researchers to assess the functional consequences of its absence on various cellular processes.

The primary mechanism by which DBNL Gene Knockout Cell Lines function relies on CRISPR-Cas9 technology, effectively creating precise double-strand breaks at the DBNL locus. This targeted disruption leads to frameshift mutations and ultimately renders the gene nonfunctional. Consequently, researchers can directly observe alterations in cell morphology, motility, and signaling pathways that are influenced by DBNL, contributing to our understanding of cellular mechanics and disease pathology.

The scientific importance of these cell lines is underscored in both research and clinical settings. They are invaluable tools for elucidating the gene's involvement in conditions such as cancer, neurodegenerative disorders, and other pathologies where actin dynamics play a crucial role. By using these knockout models, investigators can explore potential therapeutic targets and strategies, providing a foundation for advancements in gene therapy or drug discovery.

Compared to conventional knockout methods or non-specific inhibitors, DBNL Gene Knockout Cell Lines offer unmatched specificity and reproducibility. This precision allows for more reliable data generation, significantly enhancing the validity of experimental outcomes. Additionally, the ease of use of these cell lines supports high-throughput screening processes, making them a preferred choice for researchers seeking to expedite their studies without compromising on quality.

Utilizing DBNL Gene Knockout Cell Lines empowers researchers and clinicians alike to make profound discoveries in gene function and regulation, facilitating the development of innovative therapies. As a leader in genetic engineering solutions, our company is committed to providing researchers with high-quality, validated cell lines and a robust support system. Our expertise in developing biological products ensures that you are equipped with the necessary tools for your groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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