Gene: DBI
Official Full Name: diazepam binding inhibitor, acyl-CoA binding proteinprovided by HGNC
Gene Summary: This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05162 | DBI Knockout cell line (HeLa) | Human | DBI | 1:3~1:6 | Negative | Online Inquiry |
KO05163 | DBI Knockout cell line (HCT 116) | Human | DBI | 1:2~1:4 | Negative | Online Inquiry |
KO05164 | DBI Knockout cell line (HEK293) | Human | DBI | 1:3~1:6 | Negative | Online Inquiry |
KO05165 | DBI Knockout cell line (A549) | Human | DBI | 1:3~1:4 | Negative | Online Inquiry |
DBI Gene Knockout Cell Lines are highly specialized cellular models engineered to selectively deactivate the expression of the DBI (Diazepam Binding Inhibitor) gene. This innovative tool allows researchers to study the functional role of the DBI protein in various biological processes, including neuroprotection, stress response, and metabolic regulation. Through CRISPR/Cas9 technology, these cell lines are created to offer precise gene editing capabilities, making it easier for scientists to elucidate the mechanisms by which DBI influences cellular signaling pathways, receptor interactions, and gene expression profiles.
The key function of DBI Gene Knockout Cell Lines lies in their ability to serve as a blank slate for researchers aiming to investigate the consequences of DBI gene suppression. By comparing knockout cells to wild-type controls, researchers can explore the downstream effects of DBI loss-of-function, helping to uncover its potential roles in conditions such as anxiety disorders, addiction, and metabolic dysregulation. This approach is fundamental for advancing basic scientific knowledge and developing potential therapeutic strategies.
In both research and clinical settings, these knockout cell lines play a significant role. They provide a controlled system to assess the efficacy of drug candidates targeting DBI-related pathways, which could lead to new treatment options for neuropsychiatric and metabolic disorders. Moreover, these cell lines can be utilized in high-throughput screening, offering a scalable solution to evaluate compound libraries for efficacy against DBI-mediated mechanisms.
What sets DBI Gene Knockout Cell Lines apart from conventional cell models is their specificity and the advanced editing methods used in their production. Unlike RNA interference techniques that can lead to off-target effects, CRISPR/Cas9 provides an unparalleled level of precision. Additionally, the stable knockout offered by these cell lines ensures that researchers are examining the consequences of DBI loss consistently across experiments, enabling reliable data generation.
For researchers, clinicians, and pharmaceutical companies, DBI Gene Knockout Cell Lines represent a valuable resource for advancing understanding and developing interventions for critical health challenges. Our company prides itself on maintaining rigorous standards in producing high-quality biological products designed to empower scientific discovery. By investing in DBI Gene Knockout Cell Lines, clients are assured of superior tools that drive innovation and foster breakthroughs in research.
Please note that all services are for research use only. Not intended for any clinical use.
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